INT141611

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 20.32
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
lung 10
macrophage 6
muscle cells 6
microglia 4
mast cell 4
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 615 100.00 Very High Very High Very High
Inflammation 349 100.00 Very High Very High Very High
ischemia 70 99.76 Very High Very High Very High
Central nervous system 17 92.28 High High
Pain 59 84.64 Quite High
cytokine 239 82.32 Quite High
Multiple sclerosis 4 79.80 Quite High
pain pelvic 60 75.12 Quite High
interstitial cystitis 36 72.52 Quite High
Inflammatory stimuli 38 70.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 482 100.00 Very High Very High Very High
Infection 448 100.00 Very High Very High Very High
Sepsis 364 99.98 Very High Very High Very High
Metastasis 27 99.84 Very High Very High Very High
Cv General 4 Under Development 22 99.76 Very High Very High Very High
Respiratory Syncytial Virus 109 99.28 Very High Very High Very High
Endotoxemia 126 99.20 Very High Very High Very High
Renal Cancer 21 99.20 Very High Very High Very High
Sprains And Strains 36 98.56 Very High Very High Very High
Muscular Dystrophy 14 97.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data suggest that MIP-1 delta expression is increased in RBM relative to RCC and bone marrow, and may promote RBM-induced osteolysis by stimulating the recruitment and differentiation of osteoclast precursors into mature osteoclasts.
Positive_regulation (increased) of Gene_expression (expression) of MIP-1 delta in osteoclast associated with renal cancer, osteolysis and metastasis
1) Confidence 0.69 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.12 Pain Relevance 0.10
Through microarray analysis, we found expression of the chemokine, macrophage inflammatory protein-1 delta (MIP-1 delta), to be increased in RBM versus patient-matched primary RCC tissues and confirmed this finding by quantitative reverse transcription-PCR (qRT-PCR) and ELISA (P < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of MIP-1 delta in macrophage associated with chemokine, inflammation, renal cancer and metastasis
2) Confidence 0.69 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.75 Pain Relevance 0.22
Stimulation of cultured primary diaphragmatic (as well as C2C12) muscle cells with LPS triggered an upregulation of RANTES expression.
Positive_regulation (upregulation) of Gene_expression (expression) of RANTES in muscle cells
3) Confidence 0.69 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.63 Pain Relevance 0.23
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Positive_regulation (upregulated) of Gene_expression (expression) of CCR1 in lung associated with endotoxemia and infection
4) Confidence 0.69 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.69 Pain Relevance 0.22
, and this occurs to a significantly greater extent within the diaphragm as compared to limb muscle; (3) LPS-induced upregulation of RANTES expression by diaphragmatic muscle cells is transcriptionally regulated and dependent upon the NF-?
Positive_regulation (upon) of Gene_expression (expression) of RANTES in muscle cells
5) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.76 Pain Relevance 0.19
Figure 2 shows that the overall patterns of RANTES and MIP-1?
Positive_regulation (overall) of Gene_expression (overall) of RANTES
6) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.08 Pain Relevance 0.08
For example, in the mdx mouse, a murine model of Duchenne muscular dystrophy, the diaphragm exhibits a pronounced infiltration by macrophages and lymphocyctes, which parallels a marked overexpression of RANTES and MIP-1?
Positive_regulation (overexpression) of Gene_expression (overexpression) of RANTES in macrophages associated with muscular dystrophy
7) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.90 Pain Relevance 0.29
B pathway, and blockade of free radicals with the antioxidants NAC or catalase, did not have any effect on LPS-induced RANTES gene expression under the same experimental conditions, strongly suggesting that these pathways were not involved.
Positive_regulation (induced) of Gene_expression (expression) of RANTES gene
8) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.24 Pain Relevance 0.10
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Positive_regulation (increased) of Gene_expression (expression) of RANTES in lung associated with endotoxemia and infection
9) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.73 Pain Relevance 0.23
As can be seen, CCR1 and CCR5 were both expressed at a higher constitutive level in the diaphragm than in the TA limb muscle under control (saline) conditions.
Positive_regulation (level) of Gene_expression (expressed) of CCR1 in limb muscle
10) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.22 Pain Relevance 0
, and this occurs to a significantly greater extent within the diaphragm as compared to limb muscle; (3) LPS-induced upregulation of RANTES expression by diaphragmatic muscle cells is transcriptionally regulated and dependent upon the NF-?
Positive_regulation (upregulation) of Gene_expression (expression) of RANTES in muscle cells
11) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.70 Pain Relevance 0.19
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Positive_regulation (upregulated) of Gene_expression (expression) of CCR1 in lung associated with endotoxemia and infection
12) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.69 Pain Relevance 0.22
We next sought to evaluate whether the observed upregulation of CCRs in the septic diaphragm and TA is associated with altered expression of their cognate ligands, RANTES and MIP-1?
Spec (whether) Positive_regulation (associated) of Gene_expression (expression) of RANTES in diaphragm
13) Confidence 0.50 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.09 Pain Relevance 0.07
We conclude that sepsis leads to
                             greatly increased expression of RANTES, MIP-1? 
Positive_regulation (increased) of Gene_expression (expression) of RANTES associated with sepsis
14) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.51 Pain Relevance 0.14
We conclude that sepsis leads to
                             greatly increased expression of RANTES, MIP-1? 
Positive_regulation (leads) of Gene_expression (expression) of RANTES associated with sepsis
15) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.52 Pain Relevance 0.14
Through microarray analysis, we found expression of the chemokine, macrophage inflammatory protein-1 delta (MIP-1 delta), to be increased in RBM versus patient-matched primary RCC tissues and confirmed this finding by quantitative reverse transcription-PCR (qRT-PCR) and ELISA (P < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of macrophage inflammatory protein-1 delta in macrophage associated with chemokine, inflammation, renal cancer and metastasis
16) Confidence 0.44 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.75 Pain Relevance 0.22
Here we sought to study the local expression and
                             molecular regulation of the chemokines, regulated upon activation
                             normal T cell expressed and secreted (RANTES) and macrophage
                             inflammatory protein (MIP)-1?
Positive_regulation (activation) of Gene_expression (expressed) of RANTES in T cell associated with chemokine and inflammation
17) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.80 Pain Relevance 0.23
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Positive_regulation (upregulated) of Gene_expression (expressions) of CCR1 in brains associated with chemokine
18) Confidence 0.42 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.55 Pain Relevance 0.41
In vivo, PRV infection of wild-type mice induced RANTES expression in the urothelium that was temporally coincident with lamina propria mast cell accumulation (maximum at days 3-4 following infection) and was not induced in TNF(-/-) mice, TNFR1/2(-/-) mice, or mice treated with anti-TNF antibodies.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of RANTES in mast cell associated with infection
19) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17244892 Disease Relevance 1.17 Pain Relevance 0.25
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Gene_expression (expressed) of Ccr1
20) Confidence 0.39 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18

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