INT141612

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 92
Total Number 94
Disease Relevance 72.09
Pain Relevance 24.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
macrophages 9
brain 8
T cells 5
monocytes 4
lung 4
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2955 100.00 Very High Very High Very High
Inflammation 1622 100.00 Very High Very High Very High
Multiple sclerosis 1046 100.00 Very High Very High Very High
cytokine 804 100.00 Very High Very High Very High
ischemia 76 100.00 Very High Very High Very High
Inflammatory mediators 23 100.00 Very High Very High Very High
endometriosis 7 99.90 Very High Very High Very High
vagus nerve 2 99.50 Very High Very High Very High
Inflammatory response 236 99.04 Very High Very High Very High
Central nervous system 689 93.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1908 100.00 Very High Very High Very High
Multiple Sclerosis 1307 100.00 Very High Very High Very High
Cv General 4 Under Development 23 100.00 Very High Very High Very High
Endometriosis (extended) 7 99.90 Very High Very High Very High
Metastasis 54 99.84 Very High Very High Very High
Demyelinating Disease 1024 99.80 Very High Very High Very High
Infection 1437 99.62 Very High Very High Very High
Cerebral Malaria 741 99.62 Very High Very High Very High
Injury 396 99.28 Very High Very High Very High
Malaria 912 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through microarray analysis, we found expression of the chemokine, macrophage inflammatory protein-1 delta (MIP-1 delta), to be increased in RBM versus patient-matched primary RCC tissues and confirmed this finding by quantitative reverse transcription-PCR (qRT-PCR) and ELISA (P < 0.05).
Gene_expression (expression) of MIP-1 delta in macrophage associated with chemokine, inflammation, renal cancer and metastasis
1) Confidence 0.77 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.75 Pain Relevance 0.22
The receptors for MIP-1 delta, CCR1 and CCR3, were expressed in both osteoclast precursors and mature, bone-resorbing osteoclasts as shown by qRT-PCR and Western analysis.
Gene_expression (expressed) of CCR1 in osteoclasts
2) Confidence 0.77 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.55 Pain Relevance 0.19
Furthermore, MIP-1 delta expression in RBM tissues was significantly (P < 0.001) higher than in human bone marrow, suggesting a potential alteration of the bone microenvironment.
Gene_expression (expression) of MIP-1 delta in bone marrow associated with metastasis
3) Confidence 0.77 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.67 Pain Relevance 0.20
The receptors for MIP-1 delta, CCR1 and CCR3, were expressed in both osteoclast precursors and mature, bone-resorbing osteoclasts as shown by qRT-PCR and Western analysis.
Gene_expression (expressed) of MIP-1 delta in osteoclasts
4) Confidence 0.77 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.56 Pain Relevance 0.19
Taken together, these data suggest that MIP-1 delta expression is increased in RBM relative to RCC and bone marrow, and may promote RBM-induced osteolysis by stimulating the recruitment and differentiation of osteoclast precursors into mature osteoclasts.
Gene_expression (expression) of MIP-1 delta in osteoclast associated with renal cancer, osteolysis and metastasis
5) Confidence 0.77 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.12 Pain Relevance 0.10
in vivo are CCR1 and CCR5, which are both expressed by a broad spectrum of leukocytes.
Gene_expression (expressed) of CCR1 in leukocytes
6) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.61 Pain Relevance 0.25
Stimulation of cultured primary diaphragmatic (as well as C2C12) muscle cells with LPS triggered an upregulation of RANTES expression.
Gene_expression (expression) of RANTES in muscle cells
7) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.63 Pain Relevance 0.23
We next sought to evaluate whether the observed upregulation of CCRs in the septic diaphragm and TA is associated with altered expression of their cognate ligands, RANTES and MIP-1?
Gene_expression (expression) of RANTES in diaphragm
8) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.09 Pain Relevance 0.07
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Gene_expression (expression) of CCR1 in lung associated with endotoxemia and infection
9) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.68 Pain Relevance 0.22
, and this occurs to a significantly greater extent within the diaphragm as compared to limb muscle; (3) LPS-induced upregulation of RANTES expression by diaphragmatic muscle cells is transcriptionally regulated and dependent upon the NF-?
Gene_expression (expression) of RANTES in muscle cells
10) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.69 Pain Relevance 0.19
A representative autoradiograph showing CCR1 expression levels at 24 hours after LPS delivery, as well as group mean data (expressed in arbitrary units) for both time points, are provided in Figure 1.
Gene_expression (expression) of CCR1
11) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.18 Pain Relevance 0
In the absence of LPS stimulation, RANTES expression by diaphragmatic myotubes was observed, but only at a very low level, whereas MIP-1?
Gene_expression (expression) of RANTES in myotubes
12) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.16 Pain Relevance 0.15
The major findings of our study can be summarized as follows: (1) diaphragmatic CCR1 gene expression is upregulated in response to acute endotoxemia; (2) both acute endotoxemia and Pseudomonas lung infection lead to increased expression of the CCR1 ligands, RANTES and MIP-1?
Gene_expression (expression) of RANTES in lung associated with endotoxemia and infection
13) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.73 Pain Relevance 0.22
Constitutive
                             expression levels of RANTES and MIP-1?
Gene_expression (expression) of RANTES
14) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.81 Pain Relevance 0.21
In addition, under control conditions, the baseline expression levels of both RANTES and MIP-1?
Gene_expression (expression) of RANTES
15) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.31 Pain Relevance 0.12
As can be seen, CCR1 and CCR5 were both expressed at a higher constitutive level in the diaphragm than in the TA limb muscle under control (saline) conditions.
Gene_expression (expressed) of CCR1 in limb muscle
16) Confidence 0.77 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.22 Pain Relevance 0
Through microarray analysis, we found expression of the chemokine, macrophage inflammatory protein-1 delta (MIP-1 delta), to be increased in RBM versus patient-matched primary RCC tissues and confirmed this finding by quantitative reverse transcription-PCR (qRT-PCR) and ELISA (P < 0.05).
Gene_expression (expression) of macrophage inflammatory protein-1 delta in macrophage associated with chemokine, inflammation, renal cancer and metastasis
17) Confidence 0.67 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.75 Pain Relevance 0.22
Here we sought to study the local expression and
                             molecular regulation of the chemokines, regulated upon activation
                             normal T cell expressed and secreted (RANTES) and macrophage
                             inflammatory protein (MIP)-1?
Gene_expression (expressed) of RANTES in T cell associated with chemokine and inflammation
18) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.79 Pain Relevance 0.22
B pathway, and blockade of free radicals with the antioxidants NAC or catalase, did not have any effect on LPS-induced RANTES gene expression under the same experimental conditions, strongly suggesting that these pathways were not involved.
Gene_expression (expression) of RANTES gene
19) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.24 Pain Relevance 0.10
Ribonuclease protection assays were performed to quantify RANTES and MIP-1?
Gene_expression (quantify) of RANTES
20) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.17 Pain Relevance 0.16

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