INT141628

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 4.71
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cadm1) cell adhesion (Cadm1) plasma membrane (Cadm1)
Anatomy Link Frequency
olfactory nerve 3
testis 2
olfactory 2
Schwann cell 2
mast cell 2
Cadm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 19 97.56 Very High Very High Very High
Central nervous system 21 94.72 High High
Peripheral nervous system 42 91.12 High High
Sciatic nerve 38 87.60 High High
dorsal root ganglion 6 85.28 High High
Kinase C 19 82.80 Quite High
anesthesia 19 55.92 Quite High
qutenza 4 25.00 Low Low
Pyramidal cell 19 15.76 Low Low
unmyelinated 23 7.64 Low Low
Disease Link Frequency Relevance Heat
Adhesions 332 100.00 Very High Very High Very High
Targeted Disruption 6 98.40 Very High Very High Very High
Male Infertility 19 94.72 High High
Sprains And Strains 19 92.40 High High
Apoptosis 39 89.16 High High
Ganglion Cysts 6 85.28 High High
Reprotox - General 1 1 71.52 Quite High
Frailty 19 32.68 Quite Low
Wallerian Degeneration 19 29.56 Quite Low
Loss Of Sense Of Smell 19 16.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BMMCs from SgIGSF-knockout mice transplanted to the mesentery of mast cell-deficient W/W(v) mice did not degranulate in response to the mesenteric nerve stimulation, whereas transfection with SgIGSF cDNA restored those responses.
Gene_expression (transfection) of SgIGSF in mast cell associated with targeted disruption
1) Confidence 0.78 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.17 Pain Relevance 0
Spermatogenic immunoglobulin superfamily (SgIGSF) expressed on nerve and mast cells, binds homophilically between both in culture.
Gene_expression (expressed) of SgIGSF in mast cells
2) Confidence 0.78 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.14 Pain Relevance 0
The present study has revealed that, during the course of degeneration and regeneration of the olfactory epithelium following olfactory nerve transection, there is a transient increase in the expression of SgIGSF mRNA and protein.
Gene_expression (expression) of SgIGSF mRNA in olfactory epithelium
3) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.06 Pain Relevance 0
Expression of SgIGSF mRNA after olfactory nerve transection
Gene_expression (Expression) of SgIGSF mRNA in olfactory nerve
4) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.09 Pain Relevance 0
These results suggest that SgIGSF expression is upregulated in immature olfactory cells that have undergone differentiation from neural precursor cells.
Gene_expression (expression) of SgIGSF in precursor cells
5) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0 Pain Relevance 0.04
This increase seems to be accounted for by abundant expression of SgIGSF in immature olfactory cells, which are derived from basal cells and on the way to differentiation into mature olfactory cells.
Gene_expression (expression) of SgIGSF in basal cells
6) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.05 Pain Relevance 0
On the other hand, in the cases of the interactions between mast cells and fibroblasts and between spermatogenic and Sertoli cells, the latter cell populations do not express SgIGSF, implying involvement of a heterophilic binding between SgIGSF and other adhesion molecules [9, 24].
Neg (not) Gene_expression (express) of SgIGSF in Sertoli cells associated with adhesions
7) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.22 Pain Relevance 0
These results suggested that the immature olfactory cells occurring 7–11 days after the transection express SgIGSF at higher levels.
Gene_expression (express) of SgIGSF in olfactory
8) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0 Pain Relevance 0
SgIGSF (Necl-2) monomers expressed on opposing cell membranes first form a homophilic trans-dimer through interaction of their Ig-like domains, thereby causing the cells to be attached temporarily.
Gene_expression (expressed) of SgIGSF
9) Confidence 0.77 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.13 Pain Relevance 0.04
In contrast, there was no significant increase detectable in the mesentery of MITF-mutants, from which bone marrow-derived cultured mast cells (BMMCs) lack SgIGSF.
Neg (lack) Gene_expression (lack) of SgIGSF in bone marrow
10) Confidence 0.67 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.17 Pain Relevance 0
In contrast, cells with cytoplasmic staining for Gap43, located in the middle portions of the epithelium, were mostly immunopositive for SgIGSF.
Gene_expression (immunopositive) of SgIGSF in epithelium
11) Confidence 0.67 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0 Pain Relevance 0
An in vitro study showing that cultured non-neural cells forced to express SgIGSF form synapses with cultured neural cells, indicates a homophilic binding between SgIGSF molecules and suggests that SgIGSF may play biological roles in the nervous system [2].
Gene_expression (express) of SgIGSF in neural
12) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.21 Pain Relevance 0
SgIGSF is expressed not only in spermatogenic cells but also in lung and liver epithelial cells and in neurons and glia of the central and peripheral nervous systems.
Gene_expression (expressed) of SgIGSF in lung
13) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1874509 Disease Relevance 0.17 Pain Relevance 0
In the present study, we aimed to examine the expression and localization of SgIGSF in the normal adult mouse olfactory epithelium and in the epithelium undergoing regeneration after olfactory nerve transection.


Spec (examine) Gene_expression (expression) of SgIGSF in olfactory nerve
14) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.17 Pain Relevance 0.18
In a cultured cell system, an aberrant synaptic formation occurs between neurons and the non-neuronal cells forced to express SynCAM, suggesting that SgIGSF is involved in neuronal plasticity [2].
Gene_expression (express) of SynCAM in neuronal
15) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.27 Pain Relevance 0.13
Immunohistochemical studies in adult mice demonstrated that SgIGSF is expressed not only by spermatogenic cells but also by hepatocytes and bile duct epithelial cells in the liver, alveolar epithelial cells in the lung, mast cells in the connective tissue, as well as neurons and glias in the central and peripheral nervous system [9, 24, 25].
Gene_expression (expressed) of SgIGSF in hepatocytes associated with bile and peripheral nervous system
16) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.43 Pain Relevance 0.16
SgIGSF was expressed on the membrane of all olfactory, sustentacular and basal cells, but more abundantly in the apical portions of the olfactory epithelium where the dendrites of olfactory cells are in contact with sustentacular cells.
Gene_expression (expressed) of SgIGSF in olfactory
17) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1874509 Disease Relevance 0.15 Pain Relevance 0
Expression of SgIGSF mRNA in the olfactory mucosa at various times after transection of olfactory nerves was examined with RT-PCR analyses (Fig. 2).
Spec (analyses) Gene_expression (Expression) of SgIGSF mRNA in olfactory mucosa
18) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.09 Pain Relevance 0
Expression and Localization of the Cell Adhesion Molecule SgIGSF during Regeneration of the Olfactory Epithelium in Mice

Spermatogenic immunoglobulin superfamily (SgIGSF) is a cell adhesion molecule originally discovered in mouse testis.

Gene_expression (Expression) of SgIGSF in testis associated with adhesions
19) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Title Doc Link PMC1874509 Disease Relevance 0.20 Pain Relevance 0
In the present study, we examined the expression and localization of SgIGSF in mouse olfactory epithelium before and after transection of the olfactory nerves, by RT-PCR, Western blotting and immunohistochemistry.
Spec (examined) Gene_expression (expression) of SgIGSF in olfactory nerves
20) Confidence 0.60 Published 2007 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1874509 Disease Relevance 0.16 Pain Relevance 0

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