INT141629

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 2.57
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cadm1) cell adhesion (Cadm1) plasma membrane (Cadm1)
Anatomy Link Frequency
Sertoli cells 2
neural 2
nerve 1
olfactory epithelium 1
nervous system 1
Cadm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 11 61.08 Quite High
Sciatic nerve 22 57.16 Quite High
qutenza 2 25.00 Low Low
Peripheral nervous system 22 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Pyramidal cell 11 5.00 Very Low Very Low Very Low
Bile 11 5.00 Very Low Very Low Very Low
unmyelinated 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 189 99.56 Very High Very High Very High
Targeted Disruption 2 65.04 Quite High
Apoptosis 22 5.00 Very Low Very Low Very Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low
Male Infertility 11 5.00 Very Low Very Low Very Low
Frailty 11 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 11 5.00 Very Low Very Low Very Low
Wallerian Degeneration 11 5.00 Very Low Very Low Very Low
Leukemia 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spermatogenic immunoglobulin superfamily (SgIGSF) expressed on nerve and mast cells, binds homophilically between both in culture.
SgIGSF Binding (binds) of in mast cells
1) Confidence 0.48 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.14 Pain Relevance 0
Together with the results of immunoelectron microscopy showing SgIGSF immunoreactivity on the opposing membrane portions of olfactory and sustentacular cells, it is suggested that the homophilic binding between SgIGSF molecules is primarily involved in the interaction among cells in the olfactory epithelium.
SgIGSF Binding (binding) of in olfactory epithelium
2) Confidence 0.48 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.08 Pain Relevance 0
An in vitro study showing that cultured non-neural cells forced to express SgIGSF form synapses with cultured neural cells, indicates a homophilic binding between SgIGSF molecules and suggests that SgIGSF may play biological roles in the nervous system [2].
SgIGSF Binding (binding) of in neural
3) Confidence 0.48 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.22 Pain Relevance 0
Homophilic binding between SgIGSF molecules on opposing cell membranes usually means trans-dimer formation between the cis-dimers of SgIGSF on both sides [12, 18].
SgIGSF Binding (binding) of
4) Confidence 0.48 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.18 Pain Relevance 0.03
In the cultured cell systems, the cytoplasmic domain of SgIGSF is known to have two motifs that bind with several cytoplasmic proteins, namely, Dal1/Protein 4.1B, CASK, and syntenin [2, 27].
SgIGSF Binding (bind) of
5) Confidence 0.37 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.28 Pain Relevance 0
An in vitro study showing that cultured non-neural cells forced to express SgIGSF form synapses with cultured neural cells, indicates a homophilic binding between SgIGSF molecules and suggests that SgIGSF may play biological roles in the nervous system [2].
SgIGSF Binding (binding) of in neural
6) Confidence 0.37 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.22 Pain Relevance 0
A series of events follows, involving cis-dimer formation between SgIGSF and Nectin-3, trans-dimer formation between SgIGSF and Nectin-3, and replacement of SgIGSF with Nectin-1 or 2, makes the cell adhesion more stable [18, 19].
SgIGSF Binding (formation) of associated with adhesions
7) Confidence 0.37 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.23 Pain Relevance 0.03
A series of events follows, involving cis-dimer formation between SgIGSF and Nectin-3, trans-dimer formation between SgIGSF and Nectin-3, and replacement of SgIGSF with Nectin-1 or 2, makes the cell adhesion more stable [18, 19].
SgIGSF Binding (formation) of associated with adhesions
8) Confidence 0.37 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.24 Pain Relevance 0.03
On the other hand, in the cases of the interactions between mast cells and fibroblasts and between spermatogenic and Sertoli cells, the latter cell populations do not express SgIGSF, implying involvement of a heterophilic binding between SgIGSF and other adhesion molecules [9, 24].
SgIGSF Binding (binding) of in Sertoli cells associated with adhesions
9) Confidence 0.37 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.22 Pain Relevance 0
Homophilic binding between SgIGSF molecules on opposing cell membranes usually means trans-dimer formation between the cis-dimers of SgIGSF on both sides [12, 18].
SgIGSF Binding (binding) of
10) Confidence 0.37 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.18 Pain Relevance 0.03
However, it is unknown if the homophilic binding can solely account for all SgIGSF-mediated neuron-neuron and neuron-glia interactions in vivo in the nervous system.
SgIGSF Binding (interactions) of in nervous system
11) Confidence 0.36 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.22 Pain Relevance 0
On the other hand, in the cases of the interactions between mast cells and fibroblasts and between spermatogenic and Sertoli cells, the latter cell populations do not express SgIGSF, implying involvement of a heterophilic binding between SgIGSF and other adhesion molecules [9, 24].
SgIGSF Binding (binding) of in Sertoli cells associated with adhesions
12) Confidence 0.36 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.22 Pain Relevance 0
Spermatogenic immunoglobulin superfamily (SgIGSF) expressed on nerve and mast cells, binds homophilically between both in culture.
SgIGSF Binding (binds) of in nerve
13) Confidence 0.16 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox