INT141630

Context Info Confidence 0.43 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.43 Pain Relevance 0.13

cell differentiation (Cadm1) cell adhesion (Cadm1) plasma membrane (Cadm1)

Anatomy Link Frequency bone marrow 1 central nervous system 1 Cadm1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 1 99.28 Peripheral nervous system 2 85.52 Bile 1 78.08 anesthesia 1 39.20 Sciatic nerve 2 35.04 qutenza 1 25.00 Pyramidal cell 1 5.00 Kinase C 1 5.00 unmyelinated 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 1 98.40 Adhesions 18 75.00 Male Infertility 1 69.44 Sprains And Strains 1 67.12 Apoptosis 2 5.00 Frailty 1 5.00 Loss Of Sense Of Smell 1 5.00 Wallerian Degeneration 1 5.00 Leukemia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, there was no significant increase detectable in the mesentery of MITF-mutants, from which bone marrow-derived cultured mast cells (BMMCs) lack SgIGSF.

Negative_regulation (lack) of SgIGSF in bone marrow

1) Confidence 0.43 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.17 Pain Relevance 0

In developing mice, SgIGSF was shown to be distributed diffusely in the central nervous system and sensory epithelia, including the olfactory epithelium at embryonic day 16.5 [4].

Negative_regulation (distributed) of SgIGSF in central nervous system associated with central nervous system

2) Confidence 0.43 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.26 Pain Relevance 0.13

General Comments

This test has worked.