INT141631

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.42
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cadm1) cell adhesion (Cadm1) plasma membrane (Cadm1)
Anatomy Link Frequency
basal cells 4
precursor cells 2
olfactory nerve 2
olfactory epithelium 2
mast cell 2
Cadm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 82.80 Quite High
qutenza 1 25.00 Low Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
Sciatic nerve 10 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Pyramidal cell 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
unmyelinated 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 97.04 Very High Very High Very High
Apoptosis 10 89.16 High High
Adhesions 86 75.00 Quite High
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Male Infertility 5 5.00 Very Low Very Low Very Low
Frailty 5 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 5 5.00 Very Low Very Low Very Low
Wallerian Degeneration 5 5.00 Very Low Very Low Very Low
Leukemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study has revealed that, during the course of degeneration and regeneration of the olfactory epithelium following olfactory nerve transection, there is a transient increase in the expression of SgIGSF mRNA and protein.
Positive_regulation (increase) of Gene_expression (expression) of SgIGSF mRNA in olfactory epithelium
1) Confidence 0.69 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.06 Pain Relevance 0
These results suggest that SgIGSF expression is upregulated in immature olfactory cells that have undergone differentiation from neural precursor cells.
Positive_regulation (upregulated) of Gene_expression (expression) of SgIGSF in precursor cells
2) Confidence 0.69 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0 Pain Relevance 0.04
BMMCs from SgIGSF-knockout mice transplanted to the mesentery of mast cell-deficient W/W(v) mice did not degranulate in response to the mesenteric nerve stimulation, whereas transfection with SgIGSF cDNA restored those responses.
Positive_regulation (transfection) of Gene_expression (transfection) of SgIGSF in mast cell associated with targeted disruption
3) Confidence 0.50 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17250899 Disease Relevance 0.17 Pain Relevance 0
This increase seems to be accounted for by abundant expression of SgIGSF in immature olfactory cells, which are derived from basal cells and on the way to differentiation into mature olfactory cells.
Positive_regulation (abundant) of Gene_expression (expression) of SgIGSF in basal cells
4) Confidence 0.50 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.05 Pain Relevance 0
This increase seems to be accounted for by abundant expression of SgIGSF in immature olfactory cells, which are derived from basal cells and on the way to differentiation into mature olfactory cells.
Positive_regulation (accounted) of Gene_expression (expression) of SgIGSF in basal cells
5) Confidence 0.50 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.05 Pain Relevance 0
Expression of SgIGSF mRNA after olfactory nerve transection
Positive_regulation (after) of Gene_expression (Expression) of SgIGSF mRNA in olfactory nerve
6) Confidence 0.50 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.09 Pain Relevance 0

General Comments

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