INT14165

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Context Info
Confidence 0.51
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 8.35
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Ahr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 272 99.80 Very High Very High Very High
Inflammation 127 99.60 Very High Very High Very High
qutenza 14 99.48 Very High Very High Very High
COX2 4 99.12 Very High Very High Very High
tetrodotoxin 2 98.76 Very High Very High Very High
antagonist 12 98.04 Very High Very High Very High
Arthritis 4 97.96 Very High Very High Very High
Neuropeptide 12 93.68 High High
c fibre 2 92.64 High High
cytokine 19 91.48 High High
Disease Link Frequency Relevance Heat
Asthma 248 100.00 Very High Very High Very High
Respiratory Syncytial Virus 118 99.98 Very High Very High Very High
INFLAMMATION 136 99.60 Very High Very High Very High
Infection 7 98.84 Very High Very High Very High
Arthritis 8 98.56 Very High Very High Very High
Rhinitis 11 97.68 Very High Very High Very High
Sinusitis 4 96.72 Very High Very High Very High
Cough 313 94.04 High High
Pneumonia 3 92.80 High High
Cancer 11 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by inhibition of the AHR induced by S. venezuelensis infection.
Negative_regulation (inhibition) of AHR associated with infection
1) Confidence 0.51 Published 2009 Journal Microbes Infect. Section Abstract Doc Link 19114120 Disease Relevance 0.46 Pain Relevance 0.53
The link with COX2 activity inhibition and COX2 gene transcription, as well as a potential AhR inhibitory effect, remain to be established.
Negative_regulation (effect) of AhR associated with cox2
2) Confidence 0.43 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233998 Disease Relevance 0.52 Pain Relevance 0.43
Single treatments with epinastine and ketotifen did not inhibit AHR induced by repeated antigen challenge.
Negative_regulation (inhibit) of AHR
3) Confidence 0.43 Published 1991 Journal Arzneimittelforschung Section Abstract Doc Link 1687721 Disease Relevance 0.14 Pain Relevance 0.12
This AHR was significantly attenuated by systemic capsaicin pretreatment prior to sensitization.
Negative_regulation (attenuated) of AHR associated with qutenza
4) Confidence 0.37 Published 1994 Journal Life Sci. Section Abstract Doc Link 7990652 Disease Relevance 0 Pain Relevance 0.29
Furthermore, it was found that the airway NEP activity was significantly decreased at the antigen-induced AHR.
Negative_regulation (decreased) of AHR
5) Confidence 0.37 Published 1994 Journal Life Sci. Section Abstract Doc Link 7990652 Disease Relevance 0 Pain Relevance 0.26
This AHR was significantly attenuated by pretreatment with a nonselective NK-receptor antagonist, [D-Pro2,D-Trp7,9]SP, systemic capsaicin, or bilateral cervical vagotomy, indicating that decreased NEP activity results in accumulation of endogenous sensory neuropeptide(s) and enhancement of vagal reflex to cause AHR.
Negative_regulation (attenuated) of AHR associated with qutenza, antagonist and neuropeptide
6) Confidence 0.34 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7538995 Disease Relevance 0 Pain Relevance 0.33
This in vitro AHR to ACh induced by phosphoramidon plus NKA was significantly attenuated by pretreatment with 10(-6) M tetrodotoxin.
Negative_regulation (attenuated) of AHR associated with tetrodotoxin
7) Confidence 0.34 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7538995 Disease Relevance 0 Pain Relevance 0.38
Inhalation of 12.5 or 25 mg/ml ketamine markedly suppressed OVA-provoked airway hyperreactivity (AHR), airway inflammation and airway inflammatory cell infiltration into BALF, and significantly decreased OVA-induced up-regulation of iNOS, IL-4 and NO.
Negative_regulation (suppressed) of AHR associated with asthma, inflammation and ketamine
8) Confidence 0.33 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.48 Pain Relevance 0.64
Furthermore, the results of Ach-elicited airway response tests indicated that ketamine treatment by both inhaled and injected routes could attenuate OVA-induced AHR.
Negative_regulation (attenuate) of AHR associated with asthma and ketamine
9) Confidence 0.29 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.50 Pain Relevance 0.53
Data are presented that suggest that AHR-15010 and acetazolamide, a prototype carbonic anhydrase inhibitor, may present novel approaches to the treatment of arthritis.
Negative_regulation (inhibitor) of AHR-15010 associated with arthritis
10) Confidence 0.21 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1981578 Disease Relevance 0.81 Pain Relevance 0.24
AHR-15010 is a carbonic anhydrase inhibitor.
Negative_regulation (inhibitor) of AHR-15010
11) Confidence 0.21 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1981578 Disease Relevance 0.74 Pain Relevance 0.24
In our previous study, the prevalence of AHR in adults was determined to be 6.6% (3).
Negative_regulation (prevalence) of AHR
12) Confidence 0.19 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 0.96 Pain Relevance 0.09
Therefore, novel RSV derivatives with restricted activity toward ER or AhR may serve as unique tools to determine whether the effects of the parental compound RSV are due to one or the other pathway.
Negative_regulation (derivatives) of AhR associated with respiratory syncytial virus
13) Confidence 0.16 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.87 Pain Relevance 0
However, the repeatability and validity of extrathoracic AHR in children are ill-defined.
Negative_regulation (defined) of AHR
14) Confidence 0.13 Published 2005 Journal Cough Section Body Doc Link PMC1277009 Disease Relevance 1.89 Pain Relevance 0.08

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