INT141656

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 32.62
Pain Relevance 8.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 3
plasma 1
optic 1
retinal ganglion cell 1
Eae1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 291 100.00 Very High Very High Very High
Neuritis 35 100.00 Very High Very High Very High
Spinal cord 365 99.84 Very High Very High Very High
Multiple sclerosis 1277 99.80 Very High Very High Very High
Inflammation 676 99.40 Very High Very High Very High
metalloproteinase 102 99.34 Very High Very High Very High
COX-2 inhibitor 70 99.32 Very High Very High Very High
Inflammatory demyelinating syndrome 1 98.84 Very High Very High Very High
Inflammatory response 9 97.72 Very High Very High Very High
Demyelination 208 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 3118 100.00 Very High Very High Very High
Stress 419 100.00 Very High Very High Very High
Optic Neuritis 34 100.00 Very High Very High Very High
Disease 974 99.96 Very High Very High Very High
Neuromyelitis Optica 217 99.80 Very High Very High Very High
Sprains And Strains 171 99.60 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

4 99.44 Very High Very High Very High
INFLAMMATION 717 99.40 Very High Very High Very High
Demyelinating Disease 491 98.32 Very High Very High Very High
Syndrome 21 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis.
Regulation (Effect) of encephalomyelitis in optic associated with multiple sclerosis, optic neuritis and neuritis
1) Confidence 0.39 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19616065 Disease Relevance 1.63 Pain Relevance 0.74
treatment compared with vehicle-treated EAE or normal controls [Fig. 5C(iii) and (iv)].
Regulation (controls) of EAE associated with multiple sclerosis
2) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.91 Pain Relevance 0
It is widely believed that rodent EAE rarely affects the brain and is mostly limited to pathology of the spinal cord.
Regulation (affects) of EAE in spinal cord associated with multiple sclerosis and spinal cord
3) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 1.19 Pain Relevance 0.33
ligand was both anti-inflammatory and neuroprotective, the central question then became whether the neuroprotective properties of oestrogen treatment in EAE were or were not dependent upon the anti-inflammatory properties.
Neg (not) Spec (whether) Regulation (dependent) of EAE associated with multiple sclerosis and inflammation
4) Confidence 0.08 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.28 Pain Relevance 0.48
Oestriol treatment has also been shown to be effective in reducing clinical signs in EAE when administered after disease onset [129].
Regulation (effective) of EAE associated with multiple sclerosis and disease
5) Confidence 0.08 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.31 Pain Relevance 0.19
What is the effect of the other major ovarian hormone, progesterone, in EAE?
Regulation (effect) of EAE associated with multiple sclerosis
6) Confidence 0.08 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.71 Pain Relevance 0
Taken together, this shows that the pattern of MT-MMP regulation in severe EAE is independent of mouse strain, myelin antigen, and use of adjuvant in disease induction.


Neg (independent) Regulation (independent) of EAE associated with multiple sclerosis, disease and sprains and strains
7) Confidence 0.07 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.95 Pain Relevance 0.20
They injected these TREM2-expressing cells into the veins of mice with experimental autoimmune encephalomyelitis (EAE, an animal model of MS) and examined their migration into the spinal cord, their effect on EAE symptoms, and their effect on cell debris clearance and inflammatory responses in spinal cord lesions.
Spec (examined) Regulation (effect) of EAE in spinal cord associated with inflammatory response, multiple sclerosis and spinal cord
8) Confidence 0.06 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1851623 Disease Relevance 0.89 Pain Relevance 0.41
TREM2-transduced BM-MC showed an effect on the EAE disease course, leading to early and almost complete recovery from clinical symptoms.
Regulation (effect) of EAE associated with multiple sclerosis and disease
9) Confidence 0.06 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.77 Pain Relevance 0.38
has been shown to have beneficial as well as disease-exacerbating effects in EAE depending on the particular model used and the timing of antibody administration (20, 21).
Regulation (depending) of EAE associated with multiple sclerosis and disease
10) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.93 Pain Relevance 0.13
Since ovariectomy removes physiologic levels of oestradiol, as well as progesterone, data on the effect of ovariectomy on EAE is somewhat informative in this regard.
Regulation (effect) of EAE associated with multiple sclerosis
11) Confidence 0.05 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.71 Pain Relevance 0
Thus, it is controversial whether low levels of endogenous oestradiol which fluctuate during the menstrual cycle have a significant influence on EAE.
Spec (whether) Regulation (influence) of EAE associated with multiple sclerosis
12) Confidence 0.05 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.65 Pain Relevance 0
The lack of an effect of progesterone treatment on EAE was somewhat disappointing since progesterone had been shown to enhance remyelination in vitro [144-146].
Regulation (effect) of EAE associated with multiple sclerosis
13) Confidence 0.05 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.13 Pain Relevance 0.07
In both cases, the therapeutic effects in EAE were only observed when the COX-2 inhibitors were initiated immediately after immunization and maintained throughout the course of the study.
Regulation (effects) of EAE associated with multiple sclerosis, immunization and cox-2 inhibitor
14) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 2.21 Pain Relevance 1.06
Another COX-2 inhibitor nimesulid, showed no therapeutic effects in EAE in wild-type mice.
Neg (no) Regulation (effects) of EAE associated with multiple sclerosis and cox-2 inhibitor
15) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 1.50 Pain Relevance 0.56
The effects of SOD2 modulation on the EAE optic nerve were gauged by computerized analysis of optic nerve volume, myelin fiber area, and retinal ganglion cell loss at 1, 3, and 12 months after sensitization for EAE.
Regulation (modulation) of EAE in retinal ganglion cell
16) Confidence 0.04 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17251466 Disease Relevance 0.15 Pain Relevance 0
Effect of subchronic stress (12 days) on EAE
Regulation (Effect) of EAE associated with stress and multiple sclerosis
17) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.53 Pain Relevance 0.27
that are effective against EAE also correct dyslipidemia, often raising
Regulation (effective) of EAE associated with multiple sclerosis
18) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.98 Pain Relevance 0.19
Effect of chronic stress and EAE on BBB permeability, leukocyte infiltration and myelin levels in spinal cord
Regulation (Effect) of EAE in spinal cord associated with stress, multiple sclerosis and spinal cord
19) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.11 Pain Relevance 0.09
Chandler et al (2002) have already proposed that stress has a profound effect on the BBB, modulating EAE and MS.
Regulation (effect) of EAE associated with stress and multiple sclerosis
20) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 2.09 Pain Relevance 0.14

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