INT14166

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Context Info
Confidence 0.61
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 32
Total Number 35
Disease Relevance 20.78
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
CAR 1
sensory nerve 1
Ahr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 325 100.00 Very High Very High Very High
c fibre 6 99.92 Very High Very High Very High
agonist 66 99.76 Very High Very High Very High
ketamine 680 99.52 Very High Very High Very High
Inflammatory marker 15 99.28 Very High Very High Very High
antagonist 62 99.16 Very High Very High Very High
Neuropeptide 12 98.90 Very High Very High Very High
qutenza 34 97.84 Very High Very High Very High
Serotonin 1 97.64 Very High Very High Very High
endometriosis 47 97.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 991 100.00 Very High Very High Very High
Asthma 661 100.00 Very High Very High Very High
INFLAMMATION 352 100.00 Very High Very High Very High
Infection 22 99.84 Very High Very High Very High
Multiple Myeloma 24 99.60 Very High Very High Very High
Hypersensitivity 32 98.80 Very High Very High Very High
Cancer 42 98.16 Very High Very High Very High
Dyspnea 37 97.56 Very High Very High Very High
Endometriosis 52 97.46 Very High Very High Very High
Breast Cancer 8 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by inhibition of the AHR induced by S. venezuelensis infection.
Positive_regulation (induced) of AHR associated with infection
1) Confidence 0.61 Published 2009 Journal Microbes Infect. Section Abstract Doc Link 19114120 Disease Relevance 0.46 Pain Relevance 0.53
Furthermore, it was found that the airway NEP activity was significantly decreased at the antigen-induced AHR.
Positive_regulation (induced) of AHR
2) Confidence 0.59 Published 1994 Journal Life Sci. Section Abstract Doc Link 7990652 Disease Relevance 0 Pain Relevance 0.26
We secondly investigated whether the neutral endopeptidase (NEP) activity was altered at the antigen-induced AHR.
Positive_regulation (induced) of AHR
3) Confidence 0.59 Published 1994 Journal Life Sci. Section Abstract Doc Link 7990652 Disease Relevance 0 Pain Relevance 0.26
Single treatments with epinastine and ketotifen did not inhibit AHR induced by repeated antigen challenge.
Positive_regulation (induced) of AHR
4) Confidence 0.50 Published 1991 Journal Arzneimittelforschung Section Abstract Doc Link 1687721 Disease Relevance 0.14 Pain Relevance 0.12
On the other hand, chronic epinastine and ketotifen treatments, significantly inhibited the enhancement of AHR.
Positive_regulation (enhancement) of AHR
5) Confidence 0.50 Published 1991 Journal Arzneimittelforschung Section Abstract Doc Link 1687721 Disease Relevance 0.12 Pain Relevance 0.11
In addition, ALDH3c has been found to reflect the subfamily CYPIA of cytochrome P-450, as well as other enzymes functionally related to the aryl hydrocarbon receptor (the "Ah-receptor enzyme battery"), which is activated by the same type of inducers.
Positive_regulation (activated) of aryl hydrocarbon receptor
6) Confidence 0.47 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.29 Pain Relevance 0.26
In fact, a recent report revealed a complex mechanism, involved in endometriosis and other oestrogen-related traits, by which ER-mediated oestrogen signaling is modulated by a co-regulatory-like function of activated AhR/Arnt dioxin receptor complex, giving rise to adverse oestrogen-related actions of dioxin-type environmental contaminants [31].
Positive_regulation (activated) of AhR associated with endometriosis
7) Confidence 0.45 Published 2005 Journal J Exp Clin Assist Reprod Section Body Doc Link PMC1242355 Disease Relevance 0.65 Pain Relevance 0.25
The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis.
Positive_regulation (mediating) of AHR associated with c fibre, inflammation and infection
8) Confidence 0.44 Published 2009 Journal Microbes Infect. Section Abstract Doc Link 19114120 Disease Relevance 0.44 Pain Relevance 0.51
From the above results, it is suggested that chronic treatments with epinastine and ketotifen are effective even for therapy of AHR.
Positive_regulation (effective) of AHR
9) Confidence 0.44 Published 1991 Journal Arzneimittelforschung Section Abstract Doc Link 1687721 Disease Relevance 0.12 Pain Relevance 0.11
In conclusion, this is the first demonstration that, akin to viral and allergic AHR, permanent loss of sensory nerve C-fibers also reduces AHR induced by infection with a helminth.
Positive_regulation (induced) of AHR in sensory nerve associated with c fibre, hypersensitivity and infection
10) Confidence 0.41 Published 2009 Journal Microbes Infect. Section Abstract Doc Link 19114120 Disease Relevance 0.62 Pain Relevance 0.51
These findings suggest that repeated antigenic challenge causes a distinct AHR, both in vivo and in vitro, and that the airway inflammation may be closely related to pathogenesis of AHR.
Positive_regulation (causes) of AHR associated with inflammation
11) Confidence 0.40 Published 1993 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8382324 Disease Relevance 0.30 Pain Relevance 0.21
We secondly investigated whether the neutral endopeptidase (NEP) activity was altered at the antigen-induced AHR.
Positive_regulation (-) of AHR
12) Confidence 0.40 Published 1994 Journal Life Sci. Section Abstract Doc Link 7990652 Disease Relevance 0 Pain Relevance 0.26
These findings suggest that NEP hypoactivity and resultant increased sensory neuropeptides have an important role in the pathogenesis of antigen-induced AHR in rats.
Positive_regulation (induced) of AHR associated with neuropeptide
13) Confidence 0.40 Published 1994 Journal Life Sci. Section Abstract Doc Link 7990652 Disease Relevance 0 Pain Relevance 0.24
However, high wakefulness with remifentanil did not increase the AHR back to what was observed during low wakefulness without remifentanil.
Neg (not) Positive_regulation (increase) of AHR
14) Confidence 0.38 Published 2005 Journal Anesthesiology Section Body Doc Link 16052121 Disease Relevance 0.12 Pain Relevance 0
High wakefulness significantly increased AHR with and without remifentanil, whereas low wakefulness with pain did not.
Positive_regulation (increased) of AHR
15) Confidence 0.38 Published 2005 Journal Anesthesiology Section Body Doc Link 16052121 Disease Relevance 0.13 Pain Relevance 0
This triggered the result of increased AHR to Ach and an obvious airway inflammation observed 24 h after the last OVA challenge, which was in accordance with the report of Palmans et al. [26], confirming the co-existence of high airway reactivity and allergic inflammation in sensitized Brown-Norway rats after 2 weeks of OVA exposure.
Positive_regulation (increased) of AHR associated with asthma, inflammation and hypersensitivity
16) Confidence 0.36 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.15 Pain Relevance 0.29
The dioxins, furans, and coplanar PCBs (e.g., PCB-77, PCB-126) all activate AhR (Wilson and Safe 1998), whereas the more non-coplanar PCBs (e.g., PCB-52, PCB-138, PCB-153) act via CAR/PXR pathways (Connor et al. 1995; Tabb et al. 2004).
Positive_regulation (activate) of AhR in CAR
17) Confidence 0.34 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1310917 Disease Relevance 0 Pain Relevance 0.09
OVA sensitization alone has no effect on airway responsiveness and does not elicit measurable airway inflammation in this model [17,25]; in contrast a single OVA challenge induces transient AHR, and multiple OVA aerosol challenges trigger persistent AHR [17].
Positive_regulation (induces) of AHR associated with asthma and inflammation
18) Confidence 0.34 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.08 Pain Relevance 0.30
There is little controversy about the requirements for IL-4 in the induction of airway inflammation and AHR [34], while IL-13 direct causes AHR and mucus overproduction in asthma [35,36].
Positive_regulation (induction) of AHR associated with asthma and inflammation
19) Confidence 0.34 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.23 Pain Relevance 0.59
We examined the effect of nebulized ketamine inhalation on allergen-induced AHR and inflammatory changes in OVA-sensitized Brown-Norway rats, a model in which chronic OVA challenge is used to stimulate airway inflammation and AHR [17].
Positive_regulation (induced) of AHR associated with asthma, inflammation and ketamine
20) Confidence 0.34 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.08 Pain Relevance 0.54

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