INT141669

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Arpp21) cytoplasm (Arpp21)
Anatomy Link Frequency
dorsal 3
nucleus accumbens 1
Arpp21 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 6 100.00 Very High Very High Very High
Morphine 20 99.68 Very High Very High Very High
Nucleus accumbens 2 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that, in the mouse nucleus accumbens and dorsal striatum, acute administration of morphine resulted in an increase in the state of phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) at Thr34, without affecting phosphorylation at Thr75.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of cAMP-regulated phosphoprotein in dorsal associated with nucleus accumbens, dopamine and morphine
1) Confidence 0.22 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17251906 Disease Relevance 0.14 Pain Relevance 0.69
Here, we show that, in the mouse nucleus accumbens and dorsal striatum, acute administration of morphine resulted in an increase in the state of phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) at Thr34, without affecting phosphorylation at Thr75.
Positive_regulation (increase) of in nucleus accumbens Phosphorylation (phosphorylation) of cAMP-regulated phosphoprotein in dorsal associated with nucleus accumbens, dopamine and morphine
2) Confidence 0.07 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17251906 Disease Relevance 0.14 Pain Relevance 0.69

General Comments

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