INT141721

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.77
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
IB4 1
synaptic vesicles 1
central nervous system 1
cortex 1
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.8 4 99.80 Very High Very High Very High
nociceptor 6 99.32 Very High Very High Very High
substance P 4 98.48 Very High Very High Very High
Central nervous system 13 96.76 Very High Very High Very High
Peripheral nervous system 9 94.12 High High
Hippocampus 19 93.20 High High
Pain 33 85.48 High High
Inflammation 27 85.28 High High
qutenza 8 84.32 Quite High
bradykinin 1 83.00 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 9 97.96 Very High Very High Very High
Nociception 21 85.92 High High
Pain 36 85.48 High High
INFLAMMATION 45 85.28 High High
Toxicity 2 82.44 Quite High
Death 38 80.48 Quite High
Inflammatory Pain 3 80.28 Quite High
Apoptosis 10 74.72 Quite High
Ganglion Cysts 13 71.04 Quite High
Motor Neuron Diseases 214 69.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP1 immunoreactivity is abundant in DRG cell bodies and in both the peripheral and central branches of primary afferent neurons, and colocalizes with markers of nociceptors, notably substance P and IB4.
AQP1 Binding (colocalizes) of in IB4 associated with nociceptor and substance p
1) Confidence 0.37 Published 2007 Journal Pain Section Abstract Doc Link 17257750 Disease Relevance 0.06 Pain Relevance 0.31
The water transporter AQP1 in particular is of interest through its association with synaptic vesicles and participation in their swelling in cells outside the central nervous system [42].


AQP1 Binding (association) of in central nervous system associated with pressure and volume under development and central nervous system
2) Confidence 0.37 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.83 Pain Relevance 0.05
In addition, immunoprecipitation studies and single molecule tracking indicated a physical interaction between AQP-1 and Nav1.8.
AQP-1 Binding (interaction) of associated with nav1.8
3) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.57 Pain Relevance 1.22
Recent study identifies AQP1, but also AQP6, associated with synaptic vesicles [17].
AQP1 Binding (associated) of in synaptic vesicles
4) Confidence 0.35 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.31 Pain Relevance 0.44
We therefore also performed immunofluorescence analyses of motor-cortical sections to elaborate our findings (Figure 6C), demonstrating the presence of AQP1 in non-neuronal cells in the motor cortex.


AQP1 Binding (presence) of in cortex
5) Confidence 0.28 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0 Pain Relevance 0.13

General Comments

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