INT141745

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.55
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SPNS1) transmembrane transport (SPNS1)
Anatomy Link Frequency
cortex 1
motor neurons 1
SPNS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 82 100.00 Very High Very High Very High
Transcranial magnetic stimulation 28 99.22 Very High Very High Very High
Spinal cord 7 99.12 Very High Very High Very High
neuralgia 98 96.90 Very High Very High Very High
Neuropathic pain 46 95.00 High High
Action potential 18 94.88 High High
Osteoarthritis 44 85.12 High High
Lasting pain 12 80.76 Quite High
primary somatosensory cortex 6 65.28 Quite High
gABA 2 63.36 Quite High
Disease Link Frequency Relevance Heat
Pain 78 100.00 Very High Very High Very High
Motor Neuron Diseases 7 97.20 Very High Very High Very High
Neuralgia 98 96.90 Very High Very High Very High
Neuropathic Pain 64 95.00 High High
Nervous System Injury 12 92.16 High High
Osteoarthritis 44 85.12 High High
Nociception 26 81.84 Quite High
Paresis 6 81.04 Quite High
Neurological Disease 4 79.48 Quite High
Amputation 10 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also provide a review of the expression profile of 25 ReS and NRs genes in human adult spinal cord and in motor neurons of healthy and ALS individuals, using data retrieved from independent datasets obtained through serial analysis of gene expression and array investigations.
Gene_expression (expression) of NRs in motor neurons associated with motor neuron diseases and spinal cord
1) Confidence 0.67 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17259011 Disease Relevance 0.73 Pain Relevance 0.34
However, there are a number of arguments, which favor the chronic neuropathic pain as the strongest determinant of the reduced inhibition in our study: First, dividing neuralgia patients into two subgroups according to their current pain intensity revealed a significantly more pronounced motor cortex disinhibition in the moderate/severe pain (NRS?
Gene_expression (severe) of NRS in cortex associated with pain, neuralgia and neuropathic pain
2) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2898830 Disease Relevance 1.19 Pain Relevance 0.98
Immediately before starting the TMS session, the current pain intensity was assessed, and the patients were also asked to retrospectively judge the mean and maximum ongoing pain intensity during the week prior to the TMS session using a numeric rating scale (NRS; values between 0 = "no pain" to 10 = "maximal pain").
Gene_expression (values) of NRS associated with pain and transcranial magnetic stimulation
3) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2898830 Disease Relevance 1.37 Pain Relevance 1.13
There is evidence suggesting that the relative expression level of different NRs and RXR dictates the activity of individual NR pathways.
Gene_expression (expression) of NRs
4) Confidence 0.19 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.12 Pain Relevance 0
Competition for RXR among the partners of RXR is also intense due to the expression of multiple NRs in the same cell and the limited availability of RXR.
Gene_expression (expression) of NRs
5) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.13 Pain Relevance 0
First, the expression level of NRs varies among different cell types; thus, protein abundance may determine DNA binding [11].
Gene_expression (expression) of NRs
6) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

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