INT141750

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.53
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 4
heart 4
ganglion cell layer 3
brain 2
microglia 2
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 28 99.98 Very High Very High Very High
Endep 22 99.80 Very High Very High Very High
isoflurane 12 99.38 Very High Very High Very High
intrathecal 8 98.76 Very High Very High Very High
Inflammation 111 97.16 Very High Very High Very High
Antinociceptive 4 89.72 High High
aspirin 10 89.12 High High
ischemia 65 81.52 Quite High
excitatory amino acid 6 80.96 Quite High
Glutamate 10 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 100.00 Very High Very High Very High
Periodontitis 30 99.56 Very High Very High Very High
Injury 73 99.44 Very High Very High Very High
Ganglion Cysts 4 98.84 Very High Very High Very High
INFLAMMATION 140 97.16 Very High Very High Very High
Hypoxia 1 86.00 High High
Infection 5 85.64 High High
Stress 5 85.20 High High
Myocardial Infarction 2 83.64 Quite High
Hyperglycemia 2 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Positive_regulation (induced) of Localization (translocation) of p65 associated with endep, morphine and intrathecal
1) Confidence 0.67 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.74
Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus.
Positive_regulation (increased) of Localization (translocation) of p65 in nucleus associated with endep and morphine
2) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.87
Isoflurane exposure also evoked a robust increase in myocardial NO content, followed by nucleus-bound translocation of p65 or p50 subunit of NF-kappaB and increase in NF-kappaB DNA-binding activity in heart tissues.
Positive_regulation (increase) of Localization (translocation) of p65 in heart associated with isoflurane
3) Confidence 0.24 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.16 Pain Relevance 0.36
Isoflurane exposure also evoked a robust increase in myocardial NO content, followed by nucleus-bound translocation of p65 or p50 subunit of NF-kappaB and increase in NF-kappaB DNA-binding activity in heart tissues.
Positive_regulation (increase) of Localization (translocation) of p65 in heart associated with isoflurane
4) Confidence 0.24 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.22 Pain Relevance 0.37
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Positive_regulation (diabetes-induced) of Localization (translocation) of p65 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
5) Confidence 0.22 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.42 Pain Relevance 0.24
Treating rat primary microglia with BW-B70C confirmed blockage of LPS-mediated translocation of the p65 subunit of NF-?
Positive_regulation (mediated) of Localization (translocation) of p65 in microglia
6) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1526713 Disease Relevance 0.32 Pain Relevance 0.06
Inhibition by BW-B 70C of iNOS protein expression and p65 translocation in brain after IR injury
Positive_regulation (by) of Localization (translocation) of p65 in brain associated with injury
7) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.63 Pain Relevance 0.08
LPS stimulated the nuclear translocation of p65 and p50 subunits to the nucleus, and the translocation was prevented by BW-B 70C treatment (Fig. 5B–C).
Positive_regulation (stimulated) of Localization (translocation) of p65 in nucleus
8) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.32 Pain Relevance 0.07
We report here that periodontitis caused a significant increase in the nuclear translocation of the subunit p65 in the gingivomucosal tissues from ligature operated rats.
Positive_regulation (increase) of Localization (translocation) of p65 associated with periodontitis
9) Confidence 0.11 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 1.05 Pain Relevance 0.26
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Positive_regulation (diabetes-induced) of in inner nuclear layer Localization (translocation) of p65 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
10) Confidence 0.07 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.42 Pain Relevance 0.24

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