INT141751

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 11.19
Pain Relevance 5.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 7
microglial cells 2
brain 1
ganglion cell layer 1
inner nuclear layer 1
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 28 99.62 Very High Very High Very High
Endep 22 99.44 Very High Very High Very High
intrathecal 8 98.40 Very High Very High Very High
isoflurane 7 98.16 Very High Very High Very High
Inflammation 334 96.20 Very High Very High Very High
aspirin 10 88.44 High High
Antinociceptive 4 87.84 High High
chemokine 13 87.32 High High
Inflammatory response 52 85.68 High High
Spinal cord 19 84.28 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 99.82 Very High Very High Very High
Atherosclerosis 6 99.40 Very High Very High Very High
Injury 224 99.24 Very High Very High Very High
Periodontitis 30 99.08 Very High Very High Very High
Ganglion Cysts 20 98.84 Very High Very High Very High
INFLAMMATION 436 96.20 Very High Very High Very High
Albuminuria 18 93.52 High High
Brain Injury 51 92.04 High High
Hypoxia 3 85.04 High High
Infection 9 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus.
Localization (translocation) of p65 in nucleus associated with endep and morphine
1) Confidence 0.78 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.77
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Localization (translocation) of p65 associated with endep, morphine and intrathecal
2) Confidence 0.78 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.73
Isoflurane exposure also evoked a robust increase in myocardial NO content, followed by nucleus-bound translocation of p65 or p50 subunit of NF-kappaB and increase in NF-kappaB DNA-binding activity in heart tissues.
Localization (translocation) of p65 in heart associated with isoflurane
3) Confidence 0.38 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.16 Pain Relevance 0.36
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Localization (translocation) of p65 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
4) Confidence 0.33 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.41 Pain Relevance 0.24
BW-B 70C prevented nuclear translocation of p65 subunit in vivo, as demonstrated by immunohistochemistry (Fig. 3C, iii).
Localization (translocation) of p65
5) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.53 Pain Relevance 0.11
Taken together, these data suggest that BW-B 70C leads to down-regulation of iNOS gene expression by inhibiting p65 translocation to the nucleus.


Localization (translocation) of p65 in nucleus
6) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.69 Pain Relevance 0.14
It also inhibited p65 translocation to nucleus both in vitro (Fig 5B and 5D) and in vivo (Fig. 3C, iii).
Localization (translocation) of p65 in nucleus
7) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.73 Pain Relevance 0.16
Treating rat primary microglia with BW-B70C confirmed blockage of LPS-mediated translocation of the p65 subunit of NF-?
Localization (translocation) of p65 in microglia
8) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1526713 Disease Relevance 0.32 Pain Relevance 0.06
Inhibition by BW-B 70C of iNOS protein expression and p65 translocation in brain after IR injury
Localization (translocation) of p65 in brain associated with injury
9) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.63 Pain Relevance 0.08
These results indicate that inhibition of 5-LOX prevents nuclear translocation of p50/p65 complex, which may cause down-regulation of NF-?
Localization (translocation) of p65
10) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.60 Pain Relevance 0.12
LPS stimulated the nuclear translocation of p65 and p50 subunits to the nucleus, and the translocation was prevented by BW-B 70C treatment (Fig. 5B–C).
Localization (translocation) of p65 in nucleus
11) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.32 Pain Relevance 0.07
LPS stimulated the nuclear translocation of p65 and p50 subunits to the nucleus, and the translocation was prevented by BW-B 70C treatment (Fig. 5B–C).
Localization (translocation) of p65 in nucleus
12) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.32 Pain Relevance 0.07
B by BW-B 70C, we examined the effect of BW-B 70C on nuclear translocation of p50/p65 complex in LPS-treated primary microglial cells.
Localization (translocation) of p65 in microglial cells
13) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.29 Pain Relevance 0.06
The antibody recognizes an epitope overlapping the nuclear location signal of p65 subunit and therefore selectively stains released activated NF-?
Localization (released) of p65
14) Confidence 0.20 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.84 Pain Relevance 0.12
Immunohistochemistry (phase contrast resolution) shows the localization of the subunit p65 of NF-?
Localization (localization) of p65
15) Confidence 0.20 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.15 Pain Relevance 0
The staining pattern resembled the localization of the p65 expression in atherosclerotic lesions.
Localization (localization) of p65 associated with atherosclerosis
16) Confidence 0.20 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.70 Pain Relevance 0.16
 : see [67]) cause dissociation of this complex, releasing p50-p65 that then translocates to the nucleus and binds to specific ?
Localization (releasing) of p50-p65 in nucleus
17) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.28 Pain Relevance 0.04
 : see [67]) cause dissociation of this complex, releasing p50-p65 that then translocates to the nucleus and binds to specific ?
Localization (translocates) of p50-p65 in nucleus
18) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.28 Pain Relevance 0.04
We report here that periodontitis caused a significant increase in the nuclear translocation of the subunit p65 in the gingivomucosal tissues from ligature operated rats.
Localization (translocation) of p65 associated with periodontitis
19) Confidence 0.17 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.99 Pain Relevance 0.26
B p65 was decreased significantly.
Localization (decreased) of p65
20) Confidence 0.15 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.36 Pain Relevance 0.03

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