INT141752

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.96
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 4
ganglion cell layer 3
inner nuclear layer 1
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
Endep 11 100.00 Very High Very High Very High
intrathecal 4 99.50 Very High Very High Very High
aspirin 10 89.68 High High
Inflammatory response 11 86.40 High High
Antinociceptive 2 83.60 Quite High
Inflammation 84 82.80 Quite High
excitatory amino acid 3 80.96 Quite High
cINOD 7 75.00 Quite High
Glutamate 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 100.00 Very High Very High Very High
Ganglion Cysts 4 98.84 Very High Very High Very High
INFLAMMATION 111 86.04 High High
Injury 67 85.20 High High
Hyperglycemia 2 83.40 Quite High
Death 21 79.96 Quite High
Adhesions 13 79.92 Quite High
Infarction 24 76.08 Quite High
Targeted Disruption 11 75.36 Quite High
Diabetic Retinopathy 10 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Negative_regulation (prevented) of Localization (translocation) of p65 associated with endep, morphine and intrathecal
1) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.78
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Negative_regulation (inhibited) of Localization (translocation) of p65 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
2) Confidence 0.19 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.42 Pain Relevance 0.24
Taken together, these data suggest that BW-B 70C leads to down-regulation of iNOS gene expression by inhibiting p65 translocation to the nucleus.


Negative_regulation (inhibiting) of Localization (translocation) of p65 in nucleus
3) Confidence 0.19 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.69 Pain Relevance 0.14
It also inhibited p65 translocation to nucleus both in vitro (Fig 5B and 5D) and in vivo (Fig. 3C, iii).
Negative_regulation (inhibited) of Localization (translocation) of p65 in nucleus
4) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.73 Pain Relevance 0.16
BW-B 70C prevented nuclear translocation of p65 subunit in vivo, as demonstrated by immunohistochemistry (Fig. 3C, iii).
Negative_regulation (prevented) of Localization (translocation) of p65
5) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.54 Pain Relevance 0.11
Immunohistochemistry (phase contrast resolution) shows the localization of the subunit p65 of NF-?
Negative_regulation (shows) of Localization (localization) of p65
6) Confidence 0.11 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.16 Pain Relevance 0
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Negative_regulation (inhibited) of in inner nuclear layer Localization (translocation) of p65 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
7) Confidence 0.06 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.42 Pain Relevance 0.24

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