INT141759

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.18
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Nfkb1, PECAM1) mitochondrion (Nfkb1) DNA binding (Nfkb1)
protein complex (Nfkb1) cytoplasm (Nfkb1) cytosol (Nfkb1)
Nfkb1 (Rattus norvegicus)
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 99.48 Very High Very High Very High
cINOD 2 75.00 Quite High
aspirin 5 72.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
INFLAMMATION 3 99.48 Very High Very High Very High
Diabetes Mellitus 7 98.58 Very High Very High Very High
Ganglion Cysts 2 91.36 High High
Diabetic Retinopathy 5 75.00 Quite High
Hyperglycemia 1 65.72 Quite High
Death 1 62.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulfasalazine (also as a representative of the salicylates) inhibited the diabetes-induced upregulation of several inflammatory gene products, which are regulated by NF-kappaB, including vascular cell adhesion molecule, intracellular adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 in whole-retinal lysate.
NF-kappaB Regulation (regulated) of adhesion molecule associated with inflammation, diabetes mellitus and adhesions
1) Confidence 0.01 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.18 Pain Relevance 0.16

General Comments

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