INT141774

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.77
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hcn1) transmembrane transport (Hcn1)
Anatomy Link Frequency
neurons 1
sinoatrial node 1
Hcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 3 96.48 Very High Very High Very High
Analgesic 3 94.08 High High
qutenza 7 93.04 High High
Angina 3 90.72 High High
Pain 2 89.68 High High
HCN1 1 71.24 Quite High
Clonidine 3 50.00 Quite Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 1 91.24 High High
Cv General 3 Under Development 3 90.72 High High
Pain 2 89.68 High High
Retina Disease 3 86.20 High High
Disease 3 76.04 Quite High
Ganglion Cysts 3 75.00 Quite High
Nociception 1 53.20 Quite High
Arrhythmia Under Development 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCN inhibition in dystrophic mice had no effect on either extent or progression of retinal degeneration.
Negative_regulation (inhibition) of HCN
1) Confidence 0.48 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19741244 Disease Relevance 0.06 Pain Relevance 0
Effect of HCN channel inhibition on retinal morphology and function in normal and dystrophic rodents.
Negative_regulation (inhibition) of HCN
2) Confidence 0.48 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Title Doc Link 19741244 Disease Relevance 0.18 Pain Relevance 0.09
HCN inhibition enhanced the gain of frequency-response curves (FRCs) at the lowest stimulus frequencies and reduced it in the 1- to 7-Hz range.
Negative_regulation (inhibition) of HCN
3) Confidence 0.36 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19741244 Disease Relevance 0.08 Pain Relevance 0
We will then summarize our efforts to develop and validate methods for screening for novel HCN channel blockers.
Negative_regulation (blockers) of HCN
4) Confidence 0.33 Published 2009 Journal Comb. Chem. High Throughput Screen. Section Abstract Doc Link 19149492 Disease Relevance 0.27 Pain Relevance 0.31
Clonidine inhibited the native pacemaker current (I(f)) in isolated sinoatrial node pacemaker cells and the I(f)-generating hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 and HCN4 channels in transfected HEK293 cells.
Negative_regulation (inhibited) of HCN in sinoatrial node
5) Confidence 0.14 Published 2007 Journal Circulation Section Body Doc Link 17261653 Disease Relevance 0 Pain Relevance 0
Functionally, in patch-clamp experiments, some neurons were unresponsive to membrane hyperpolarization, thus, probably lacking HCN channels.
Negative_regulation (lacking) of HCN in neurons
6) Confidence 0.01 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18218331 Disease Relevance 0.19 Pain Relevance 0.58

General Comments

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