INT141793

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.32
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ucp3) aging (Ucp3) transmembrane transport (Ucp3)
Anatomy Link Frequency
skeletal muscle 8
visceral 2
liver 2
fat 2
muscle 2
Ucp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 20 99.98 Very High Very High Very High
corticosteroid 96 73.52 Quite High
Inflammation 12 37.44 Quite Low
cytokine 12 36.20 Quite Low
qutenza 2 25.00 Low Low
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 80 99.64 Very High Very High Very High
Metabolic Syndrome 8 97.80 Very High Very High Very High
Diabetes Mellitus 45 97.00 Very High Very High Very High
Obesity 69 92.32 High High
Body Weight 39 74.48 Quite High
INFLAMMATION 12 37.44 Quite Low
Weight Gain 20 34.76 Quite Low
Repression 4 12.96 Low Low
Disorder Of Lipid Metabolism 35 5.00 Very Low Very Low Very Low
Exsanguination 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the corresponding enhanced UCP3 mRNA expression occurring in the control group after muscle stimulation, one can suggest that changes in FFA level and UCP3 mRNA expression are not mechanistically correlated.
Positive_regulation (enhanced) of Gene_expression (expression) of UCP3 mRNA in muscle
1) Confidence 0.70 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17264228 Disease Relevance 0 Pain Relevance 0
A possible hepatic mechanism for decreasing visceral adiposity is that fenofibrate increases hepatic energy dissipation via de novo expression of UCP-3 in mitochondria.
Positive_regulation (increases) of Gene_expression (expression) of UCP-3 in visceral
2) Confidence 0.64 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.08 Pain Relevance 0
A recent report by Linn et al. (23) showed that fenofibrate induced de novo expression of UCP-3 in the liver of Winstar rats.
Positive_regulation (induced) of Gene_expression (expression) of UCP-3 in liver
3) Confidence 0.64 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0 Pain Relevance 0
There is strong evidence that increased fat metabolism is associated with increased expression of UCP-2 and UCP-3 (14, 15).
Positive_regulation (increased) of Gene_expression (expression) of UCP-3 in fat
4) Confidence 0.64 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.74 Pain Relevance 0
In this study we observed that fenofibrate did not significantly increase the expression of UCP-2 mRNA and UCP-3 mRNA in skeletal muscle, but induced newly expressed UCP-3 mRNA in hepatic tissues.
Positive_regulation (induced) of Gene_expression (expressed) of UCP-3 mRNA in skeletal muscle
5) Confidence 0.64 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.07 Pain Relevance 0
Dexamethasone leads to increased expression of UCP3 in skeletal muscle in rats and mice (Gong et al. 1997; Sun et al. 2003).
Positive_regulation (leads) of Gene_expression (expression) of UCP3 in skeletal muscle associated with dexamethasone
6) Confidence 0.59 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.12
Two probe sets for UCP3 exhibit similar expression versus time patterns and yield similar parameter estimates, suggesting good reproducibility of the oligonucleotide microarray assay.
Positive_regulation (sets) of Gene_expression (expression) of UCP3
7) Confidence 0.43 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Enhanced expressions of both UCP3 and PDK4 in skeletal muscle have been associated with obesity and type II diabetes in humans (Bao et al. 1998; Sugden and Holness, 2002).
Positive_regulation (Enhanced) of Gene_expression (expressions) of UCP3 in skeletal muscle associated with diabetes mellitus and metabolic syndrome
8) Confidence 0.40 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.35 Pain Relevance 0.04
Dexamethasone leads to increased expression of UCP3 in skeletal muscle in rats and mice (Gong et al. 1997; Sun et al. 2003).
Positive_regulation (increased) of Gene_expression (expression) of UCP3 in skeletal muscle associated with dexamethasone
9) Confidence 0.40 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.12
The increased body core temperature and hepatic UCP-3 expression induced by fenofibrate supports the hypothesis that hepatic UCP-3 works as an uncoupler protein rather than an exporter protein.
Positive_regulation (induced) of Gene_expression (expression) of UCP-3 in body
10) Confidence 0.37 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.07 Pain Relevance 0

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