INT14182

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 10.06
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPB1) extracellular region (CPB1)
Anatomy Link Frequency
liver 2
cardiomyocytes 1
body 1
CPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 93.20 High High
anesthesia 34 92.84 High High
Opioid 3 91.36 High High
medulla 2 90.82 High High
Pain 4 88.16 High High
Versed 5 88.00 High High
isoflurane 6 86.88 High High
Bile 4 85.76 High High
antagonist 4 85.24 High High
palliative 1 84.24 Quite High
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 5 99.84 Very High Very High Very High
Pancreatitis 23 99.72 Very High Very High Very High
Prostate Cancer 1 98.88 Very High Very High Very High
Acidosis 6 97.02 Very High Very High Very High
Multiple Organ Failure 52 97.00 Very High Very High Very High
Benign Prostatic Hypertrophy 1 96.92 Very High Very High Very High
Hypothermia 46 95.80 Very High Very High Very High
Heart Rate Under Development 21 95.72 Very High Very High Very High
Increased Venous Pressure Under Development 25 95.26 Very High Very High Very High
Anti-phospholipid Antibody Syndrome 79 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At admission, peak levels of PASP (average value, 1,976 +/- 329 ng/ml), pancreatic isoamylase (942 +/- 151 U/L) and lipase (2,946 +/- 534 U/L) were detected in 15 of 20, 16 of 20, and 12 of 20 cases, respectively.
Gene_expression (detected) of PASP
1) Confidence 0.67 Published 1995 Journal Pancreas Section Abstract Doc Link 7624299 Disease Relevance 0.69 Pain Relevance 0.11
Maximal PASP, amylase, and lipase levels were found in 11 of 12, nine of 12, and five of 12 patients, respectively, on the day of admission.
Gene_expression (levels) of PASP
2) Confidence 0.60 Published 1995 Journal Pancreas Section Abstract Doc Link 7624299 Disease Relevance 0.59 Pain Relevance 0.18
Eight patients of 173 with acute abdominal disorders and no evidence of pancreatitis had elevated PASP levels as well as 4 patients with prostatic carcinoma (n = 28) and 2 patients with benign prostatic hyperplasia (n = 16).
Gene_expression (levels) of PASP associated with benign prostatic hypertrophy, pancreatitis and prostate cancer
3) Confidence 0.52 Published 1990 Journal Pancreas Section Abstract Doc Link 1688389 Disease Relevance 1.00 Pain Relevance 0.15
At present, more analysis is needed to explore the surgical complications of these patients, in terms of graft patency for CPB versus OPCAB groups, and also long term prospective neurological outcome after CPB-technique, as suggested by previous studies.
Gene_expression (groups) of CPB
4) Confidence 0.51 Published 2006 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2323524 Disease Relevance 0.36 Pain Relevance 0
For example, increased tissue oxygen pressure in the renal medulla and decreased local lactate levels have been found in CPB with IABP.16 On the other hand, CPB without IABP has been associated with renal hypoxia and acidosis.17,18 Likewise, progressive systemic arterial vasoconstriction has been demonstrated in the absence of IABP, leading to reduced perfusion and acidosis.19 Similar findings have emerged from studies of the splanchnic circulation, with reduced frequency of elevated amylase levels observed in patients receiving CPB with IABP.20 IABP during CPB preserves the liver, decreasing aspartate aminotransferase leakage.21 More recently, the benefit of IABP during CPB has been investigated in an elderly population by Onorati and colleagues.22 A significant improvement in respiratory function was found, and it was concluded that IABP-induced pulsatile flow significantly improves whole-body perfusion.


Gene_expression (receiving) of CPB in liver associated with medulla, acidosis, hypoxia and increased venous pressure under development
5) Confidence 0.30 Published 2010 Journal The Journal of Thoracic and Cardiovascular Surgery Section Body Doc Link PMC2891860 Disease Relevance 0.38 Pain Relevance 0.05
In the present study, a significant but similar percentage of cardiomyocytes were Fas positive before CPB in both groups.
Gene_expression (positive) of CPB in cardiomyocytes
6) Confidence 0.29 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.80 Pain Relevance 0.03
For example, increased tissue oxygen pressure in the renal medulla and decreased local lactate levels have been found in CPB with IABP.16 On the other hand, CPB without IABP has been associated with renal hypoxia and acidosis.17,18 Likewise, progressive systemic arterial vasoconstriction has been demonstrated in the absence of IABP, leading to reduced perfusion and acidosis.19 Similar findings have emerged from studies of the splanchnic circulation, with reduced frequency of elevated amylase levels observed in patients receiving CPB with IABP.20 IABP during CPB preserves the liver, decreasing aspartate aminotransferase leakage.21 More recently, the benefit of IABP during CPB has been investigated in an elderly population by Onorati and colleagues.22 A significant improvement in respiratory function was found, and it was concluded that IABP-induced pulsatile flow significantly improves whole-body perfusion.


Gene_expression (receiving) of CPB in liver associated with medulla, acidosis, hypoxia and increased venous pressure under development
7) Confidence 0.26 Published 2010 Journal The Journal of Thoracic and Cardiovascular Surgery Section Body Doc Link PMC2891860 Disease Relevance 0.38 Pain Relevance 0.05
Both groups had normal blood lactate levels throughout the study, indicating that a gross mismatch of whole body oxygen delivery and consumption during CPB did not occur.
Gene_expression (consumption) of CPB in body
8) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.37 Pain Relevance 0.07
The standardized CPB priming consisted of 600 ml of crystalloid fluid, 500 ml of 10% hydroxyethylstarch solution and a total dose of 50,000 KIU aprotinin per kg bodyweight prior to and during CPB.
Gene_expression (priming) of CPB
9) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.42 Pain Relevance 0.35
Anesthetic and CPB technique, isovolemic hemodilution and management in the intensive care unit
Gene_expression (technique) of CPB
10) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.88 Pain Relevance 0.46
To begin with the origin of S100B measured after CPB is not exclusively cerebral.
Gene_expression (measured) of CPB
11) Confidence 0.12 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.08 Pain Relevance 0
Taylor and coworkers [13] found that autoregulation is preserved during normothermic CPB, it begins to be altered at temperature less than 25°C, and it is lost at temperature less than 20°C, while previous studies had shown that autoregulation is intact during moderately hypothermic CPB (25° to 32°C) [10], and it is lost during deep hypothermic CPB (18° to 22°C) (Figure 3).
Gene_expression (lost) of CPB
12) Confidence 0.12 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.21 Pain Relevance 0
During CPB, CBF increases with increasing arterial carbon dioxide tension, but this response is diminished by deep hypothermia and age less than 1 year.
Gene_expression (During) of CPB associated with hypothermia
13) Confidence 0.12 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.24 Pain Relevance 0
During CPB rewarming, CBF returns to baseline values, except in patients exposed to periods of DHCA where CBF remains decreased (Figure 5) [15].
Gene_expression (rewarming) of CPB
14) Confidence 0.12 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.15 Pain Relevance 0.04
Normal coupling of CBF/CMRO2 is present before and after CPB, as well as during normothermic CPB and ?
Gene_expression (present) of CPB
15) Confidence 0.12 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.15 Pain Relevance 0.03
Taylor and coworkers [13] found that autoregulation is preserved during normothermic CPB, it begins to be altered at temperature less than 25°C, and it is lost at temperature less than 20°C, while previous studies had shown that autoregulation is intact during moderately hypothermic CPB (25° to 32°C) [10], and it is lost during deep hypothermic CPB (18° to 22°C) (Figure 3).
Gene_expression (preserved) of CPB
16) Confidence 0.12 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.21 Pain Relevance 0
Normal coupling of CBF/CMRO2 is present before and after CPB, as well as during normothermic CPB and ?
Gene_expression (present) of CPB
17) Confidence 0.12 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.14 Pain Relevance 0.03
Bivalirudin is a bivalent reversible direct thrombin inhibitor and has been used safely for CPB in HIT-positive patients [56,72,74-76].
Gene_expression (used) of CPB associated with heparin-induced thrombocytopenia
18) Confidence 0.11 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.51 Pain Relevance 0.06
CABG procedures were divided into three periods: pre-CPB, during CPB, and post-CPB.
Gene_expression (during) of CPB
19) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550964 Disease Relevance 0.18 Pain Relevance 0.03
CABG procedures were divided into three periods: pre-CPB, during CPB, and post-CPB.
Gene_expression (during) of CPB
20) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550964 Disease Relevance 0.18 Pain Relevance 0.03

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