INT141833

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.57
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (WNT1) extracellular space (WNT1) extracellular region (WNT1)
proteinaceous extracellular matrix (WNT1) plasma membrane (WNT1) cell-cell signaling (WNT1)
Anatomy Link Frequency
stem cell 1
T-cell 1
WNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 80 98.28 Very High Very High Very High
vincristine 4 98.12 Very High Very High Very High
Dopamine 2 95.84 Very High Very High Very High
Spinal cord 3 95.00 High High
Neurotransmitter 14 94.20 High High
metalloproteinase 6 87.68 High High
Kinase C 24 86.56 High High
Central nervous system 2 73.44 Quite High
substance P 1 72.80 Quite High
antagonist 58 72.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 443 100.00 Very High Very High Very High
Apoptosis 166 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 6 99.52 Very High Very High Very High
Targeted Disruption 10 98.80 Very High Very High Very High
Carcinoma 32 97.52 Very High Very High Very High
Breast Cancer 72 96.64 Very High Very High Very High
Neurodegenerative Disease 16 96.04 Very High Very High Very High
Lung Cancer 18 95.52 Very High Very High Very High
Hyperplasia 2 94.48 High High
Ovarian Cancer 2 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, we found that other NSAIDs including indomethacin, resveratrol, and SC-560 induced apoptosis and suppressed the expression of survivin and the Wnt/beta-catenin signaling pathway in HCT-116 cells, indicating that these effects were likely to be common among NSAIDs.
Gene_expression (expression) of Wnt associated with cinod and apoptosis
1) Confidence 0.75 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.50 Pain Relevance 0.53
Celecoxib also suppressed the activity of TOPflash, T-cell factor reporter plasmid, and the reporter gene driven by the human cyclin D1 promoter, suggesting that this compound inhibited the expression of Wnt/beta-catenin signaling target genes.
Gene_expression (expression) of Wnt in T-cell
2) Confidence 0.75 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.50 Pain Relevance 0.50
Wnt1 expression [42] in both primary MSCs and B10 cells increased markedly after bFGF treatment.
Gene_expression (expression) of Wnt1
3) Confidence 0.47 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.29 Pain Relevance 0.05
Recent studies have revealed that the Wnt-1 overexpression, resulting in an aberrant and stabilized ?
Gene_expression (overexpression) of Wnt-1
4) Confidence 0.31 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.66 Pain Relevance 0.04
A transgenic mouse model has recently shown that tumor growth is dependent on Wnt-1 expression [45].
Gene_expression (expression) of Wnt-1 associated with targeted disruption and cancer
5) Confidence 0.26 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.06 Pain Relevance 0.04
Chen and colleagues showed that cells expressing Wnt1 were resistant to cancer therapy mediated apoptosis.Wnt1 signaling inhibited cytochrome c release and the subsequent caspase-9 activation that was induced by chemotherapeutic drugs, including both vincristine and vinblastine.
Gene_expression (expressing) of Wnt1 associated with vincristine, cancer and apoptosis
6) Confidence 0.26 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.21 Pain Relevance 0.09
A recent study on NSCLC has disclosed that the Wnt1 expression correlates with the intratumoral VEGF-A expression with the action of elevating the activity of Wnt/?
Gene_expression (expression) of Wnt1 associated with non-small-cell lung cancer
7) Confidence 0.24 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.09 Pain Relevance 0.06
Using similar neurogenic medium (NPMM or Neurobasal), MSC expressed dopaminergic specific genes (En1, En2, LMx1a, Wnt1, Ptx3, and Nuur1 and were positive to GFAP, MAP-2 and NSE but continued to express the neural stem cell marker nestin.
Gene_expression (expressed) of Wnt1 in stem cell
8) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.24
Chen and colleagues showed that cells expressing Wnt1 were resistant to cancer therapy mediated apoptosis.Wnt1 signaling inhibited cytochrome c release and the subsequent caspase-9 activation that was induced by chemotherapeutic drugs, including both vincristine and vinblastine.
Gene_expression (resistant) of Wnt1 associated with vincristine, cancer and apoptosis
9) Confidence 0.22 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.27 Pain Relevance 0.09
Further research showed that Wnt1 signaling inhibited apoptosis by activating ?
Gene_expression (signaling) of Wnt1 associated with apoptosis
10) Confidence 0.22 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.21 Pain Relevance 0.09
Wnt1 was originally discovered as an oncogene activated by mouse mammary tumor virus (MMTV) [5], and mice engineered to express either Wnt1 or an activated form of ?
Gene_expression (express) of Wnt1 associated with cancer
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.54 Pain Relevance 0
Wnt1 was originally discovered as an oncogene activated by mouse mammary tumor virus (MMTV) [5], and mice engineered to express either Wnt1 or an activated form of ?
Gene_expression (discovered) of Wnt1 associated with cancer
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.51 Pain Relevance 0
Treatment with EA reduced Wnt1/LRP6 or Wnt3/LRP6, Dvl, and ?
Gene_expression (/) of Wnt1
13) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.30 Pain Relevance 0.17
-catenin pathway, the TOPflash reporter was activated by Wnt1/LRP6 or Wnt3/LRP6, Dvl and ?
Gene_expression (/) of Wnt1
14) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.18 Pain Relevance 0.20
The expression plasmids encoding Wnt1, Wnt3, LRP6, Dvl, ?
Gene_expression (expression) of Wnt1
15) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.17 Pain Relevance 0

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