INT141834

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.31
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (WNT1) extracellular space (WNT1) extracellular region (WNT1)
proteinaceous extracellular matrix (WNT1) plasma membrane (WNT1) cell-cell signaling (WNT1)
Anatomy Link Frequency
T-cell 2
WNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 16 98.58 Very High Very High Very High
antagonist 3 68.08 Quite High
imagery 1 38.92 Quite Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 30 99.90 Very High Very High Very High
Colon Cancer 11 80.88 Quite High
INFLAMMATION 3 65.72 Quite High
Chronic Lymphoid Leukemia 76 63.52 Quite High
Cancer 7 56.16 Quite High
Toxicity 3 50.00 Quite Low
Death 5 12.96 Low Low
Stress 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Celecoxib also suppressed the activity of TOPflash, T-cell factor reporter plasmid, and the reporter gene driven by the human cyclin D1 promoter, suggesting that this compound inhibited the expression of Wnt/beta-catenin signaling target genes.
Negative_regulation (inhibited) of Gene_expression (expression) of Wnt in T-cell
1) Confidence 0.57 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.50 Pain Relevance 0.50
Further, we found that other NSAIDs including indomethacin, resveratrol, and SC-560 induced apoptosis and suppressed the expression of survivin and the Wnt/beta-catenin signaling pathway in HCT-116 cells, indicating that these effects were likely to be common among NSAIDs.
Negative_regulation (suppressed) of Gene_expression (expression) of Wnt associated with cinod and apoptosis
2) Confidence 0.41 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.50 Pain Relevance 0.54
Treatment with EA reduced Wnt1/LRP6 or Wnt3/LRP6, Dvl, and ?
Negative_regulation (reduced) of Gene_expression (/) of Wnt1
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.30 Pain Relevance 0.17

General Comments

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