INT141835

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (WNT1) extracellular space (WNT1) extracellular region (WNT1)
proteinaceous extracellular matrix (WNT1) plasma membrane (WNT1) cell-cell signaling (WNT1)
WNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 98.58 Very High Very High Very High
Catecholamine 1 88.64 High High
Calcium channel 1 87.64 High High
sodium channel 1 85.84 High High
Nav1.7 1 85.24 High High
ischemia 1 77.04 Quite High
Inflammation 1 74.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 4 99.90 Very High Very High Very High
Colon Cancer 4 80.88 Quite High
Cv Unclassified Under Development 1 77.04 Quite High
Neurodegenerative Disease 1 76.64 Quite High
Disease 2 75.00 Quite High
INFLAMMATION 2 74.44 Quite High
Diabetes Mellitus 1 73.88 Quite High
Attention Deficit Hyperactivity Disorder 1 66.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, we found that other NSAIDs including indomethacin, resveratrol, and SC-560 induced apoptosis and suppressed the expression of survivin and the Wnt/beta-catenin signaling pathway in HCT-116 cells, indicating that these effects were likely to be common among NSAIDs.
Negative_regulation (suppressed) of Wnt associated with cinod and apoptosis
1) Confidence 0.41 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17270149 Disease Relevance 0.50 Pain Relevance 0.54
Comprehensive review articles about lithium (1), GSK-3 and GSK-3 inhibitors (2-4), and the inhibition of Wnt/GSK-3beta>/beta-catenin signaling pathway by therapeutic drugs (5) are useful.
Negative_regulation (inhibition) of Wnt
2) Confidence 0.41 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273146 Disease Relevance 0.51 Pain Relevance 0.29

General Comments

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