INT14184

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Context Info
Confidence 0.55
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 14.38
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPB1) extracellular region (CPB1)
Anatomy Link Frequency
lung 2
tube 1
brain 1
chest 1
band 1
CPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 23 100.00 Very High Very High Very High
Inflammation 61 99.60 Very High Very High Very High
Inflammatory response 10 97.40 Very High Very High Very High
cytokine 23 91.84 High High
fibrosis 36 91.12 High High
alcohol 4 90.64 High High
Pain 4 87.60 High High
chemokine 1 86.80 High High
palliative 2 82.56 Quite High
tissue acidosis 2 80.64 Quite High
Disease Link Frequency Relevance Heat
Injury 45 100.00 Very High Very High Very High
Reperfusion Injury 15 100.00 Very High Very High Very High
Necrosis 17 99.98 Very High Very High Very High
Pancreatitis 14 99.90 Very High Very High Very High
Pleural Effusion 14 99.90 Very High Very High Very High
Aging 3 99.76 Very High Very High Very High
Adrenal Insufficiency 82 99.74 Very High Very High Very High
INFLAMMATION 72 99.60 Very High Very High Very High
Pulmonary Hypertension 18 99.48 Very High Very High Very High
Pneumothorax 16 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While our results confirm the expected finding that the prevalence of arrhythmias increases after CPB, they also revealed that children with pre-operative arrhythmias were significantly more likely to have postoperative arrhythmias.
Positive_regulation (increases) of CPB
1) Confidence 0.55 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2974677 Disease Relevance 0.55 Pain Relevance 0
The elevations were generally parallel for the two analytes, but in 41% of the cases PASP levels remained elevated 2-11 days longer than the corresponding amylase levels.
Positive_regulation (elevated) of PASP
2) Confidence 0.54 Published 1990 Journal Pancreas Section Abstract Doc Link 1688389 Disease Relevance 0.75 Pain Relevance 0.09
Therefore, CBF/CMRO2 during DHCPB increases favouring luxury perfusion of the brain.
Positive_regulation (increases) of CPB in brain
3) Confidence 0.49 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.14 Pain Relevance 0.03
CONCLUSION: A myasthenic patient can safely undergo CPB provided adequate preoperative optimization is achieved.
Positive_regulation (undergo) of CPB
4) Confidence 0.41 Published 2003 Journal Middle East J Anesthesiol Section Body Doc Link 14503130 Disease Relevance 0.07 Pain Relevance 0
Pneumothorax develops in 3–15% of patients undergoing CPB, and of these patients, 1% requires chest tube drainage [1,3,4].
Positive_regulation (undergoing) of CPB in tube associated with pneumothorax
5) Confidence 0.41 Published 2008 Journal Cases J Section Body Doc Link PMC2584077 Disease Relevance 1.94 Pain Relevance 0.14
We report a patient with an exudative unilateral pleural effusion who underwent a CPB and suffered a severe complication of this procedure.


Positive_regulation (underwent) of CPB associated with pleural effusion
6) Confidence 0.41 Published 2008 Journal Cases J Section Body Doc Link PMC2584077 Disease Relevance 1.26 Pain Relevance 0.08
Following approval by our institution's Human Ethical Committee and the parents' informed consent, 494 consecutive patients undergoing CPB for corrective surgery of congenital cardiac defects were enrolled prospectively between November of 1993 and February of 2000: 96 neonates, aged 1-28 days, with a median age of 9 days, and 398 infants and children between 29 days and 18 years of age, with a median age of 3.7 years.
Positive_regulation (undergoing) of CPB
7) Confidence 0.37 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2974677 Disease Relevance 0.08 Pain Relevance 0
Eight patients of 173 with acute abdominal disorders and no evidence of pancreatitis had elevated PASP levels as well as 4 patients with prostatic carcinoma (n = 28) and 2 patients with benign prostatic hyperplasia (n = 16).
Positive_regulation (elevated) of PASP associated with benign prostatic hypertrophy, pancreatitis and prostate cancer
8) Confidence 0.36 Published 1990 Journal Pancreas Section Abstract Doc Link 1688389 Disease Relevance 1.00 Pain Relevance 0.15
The major finding of our study was that the use of etomidate was an independent risk factor for RAI in patients undergoing CPB.
Positive_regulation (undergoing) of CPB associated with adrenal insufficiency
9) Confidence 0.36 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2867788 Disease Relevance 0.69 Pain Relevance 0.10
We studied an elderly population undergoing CPB, and more pronounced RAI was observed in patients over 60 years compared with their younger counterparts.
Positive_regulation (undergoing) of CPB associated with adrenal insufficiency
10) Confidence 0.36 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2867788 Disease Relevance 0.39 Pain Relevance 0
It is important to note that there are multiple factors involved in contributing to inflammatory injury, apart from CPB, such as surgical trauma, ischaemic-reperfusion injury and thrombin activation (19).
Positive_regulation (activation) of CPB associated with reperfusion injury, inflammation and injury
11) Confidence 0.36 Published 2006 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2323524 Disease Relevance 0.98 Pain Relevance 0.26
Increased pulmonary arterial diastolic pressure post-CPB was a predictor of mortality (OR 1.2, P = 0.004), stroke (OR 3.9, P = 0.002), and PMI (OR 2.2, P = 0.001).
Positive_regulation (Increased) of post-CPB associated with stroke and myocardial infarction
12) Confidence 0.31 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10512249 Disease Relevance 2.00 Pain Relevance 0.07
Molecular markers of myocardial necrosis increased after CPB in a similar way in both groups, with the exception of lactate dehydrogenase that did not change consistently after reperfusion, and creatine kinase myocardial band that rose only in the MiHT group.

4.

Neg (exception) Positive_regulation (increased) of CPB in band associated with necrosis
13) Confidence 0.20 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 1.04 Pain Relevance 0.03
Although results from controlled clinical studies reported similar or beneficial outcome after normothermic CPB [17,18], cardiac surgical practice still performs CPB over a broad range of temperatures.
Positive_regulation (performs) of CPB
14) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.17 Pain Relevance 0
Results from controlled trials investigating the effect of hemodilution on oxygen delivery and clinical outcome in patients undergoing normothermic CPB have not yet been published.
Positive_regulation (undergoing) of CPB
15) Confidence 0.16 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.05 Pain Relevance 0
CPB using a membrane oxygenator is, however, used for 1?
Positive_regulation (used) of CPB
16) Confidence 0.11 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.60 Pain Relevance 0.14
40 mmHg was found in 11.8% of the patients with abnormal PFTs and/or signs or symptoms of lung involvement: in 7.5% of cases elevated PASP could be secondary to interstitial lung disease, less than reported in a large cohort of scleroderma patients in which a restrictive ventilatory defect was observed in 22% of the patients and secondary PAH in 18% of the patients [30].
Positive_regulation (elevated) of PASP in lung associated with pulmonary hypertension, interstitial lung diseases and systemic sclerosis
17) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1208954 Disease Relevance 0.96 Pain Relevance 0.06
To account for the expected increase in PASP with aging, PAH was considered present if PASP exceeded 40 mmHg [17].
Positive_regulation (increase) of PASP associated with pulmonary hypertension and aging
18) Confidence 0.03 Published 2005 Journal Respir Res Section Body Doc Link PMC1208954 Disease Relevance 0.54 Pain Relevance 0.12
In 7 (7.5%) patients elevated PASP was considered secondary to interstitial lung disease (see also Additional file 1).
Positive_regulation (elevated) of PASP in lung associated with interstitial lung diseases
19) Confidence 0.03 Published 2005 Journal Respir Res Section Body Doc Link PMC1208954 Disease Relevance 0.27 Pain Relevance 0.09
Pexelizumab has also been studied in patients undergoing cardiac surgery requiring CPB.
Positive_regulation (requiring) of CPB
20) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.23 Pain Relevance 0.07

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