INT141841

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.15
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sensory neurons 2
neurons 2
SAN 2
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 94 100.00 Very High Very High Very High
sodium channel 20 100.00 Very High Very High Very High
Nav1.1 6 100.00 Very High Very High Very High
Pain 32 99.92 Very High Very High Very High
dorsal root ganglion 62 99.36 Very High Very High Very High
Nav1.6 6 99.28 Very High Very High Very High
nav1.3 3 98.08 Very High Very High Very High
Nav1.2 2 97.64 Very High Very High Very High
Neuropathic pain 15 96.40 Very High Very High Very High
Nav1.7 3 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 35 99.92 Very High Very High Very High
Myocardial Infarction 7 99.70 Very High Very High Very High
Hypersensitivity 7 99.56 Very High Very High Very High
Ganglion Cysts 62 99.36 Very High Very High Very High
Neuropathic Pain 26 96.40 Very High Very High Very High
Cancer Pain 24 96.00 Very High Very High Very High
Hyperalgesia 11 94.40 High High
Injury 45 87.80 High High
Causalgia 1 76.68 Quite High
Cancer 41 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HF significantly decreased SAN sodium channel expression at both the protein and mRNA levels (Nav1.1 by 61 and 71%, Nav1.6 by 49 and 46%, respectively).
Negative_regulation (decreased) of Transcription (levels) of Nav1 in SAN associated with nav1.1, sodium channel, nav1.6 and myocardial infarction
1) Confidence 0.43 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.58 Pain Relevance 1.77
Nav1.8 mRNA and protein levels decreased in ipsilateral DRG neurons, especially in small neurons, concomitantly with the occurrence of stable ambulatory-evoked pain and mechanical hyperalgesia.
Negative_regulation (decreased) of Transcription (levels) of Nav1 in neurons associated with pain, dorsal root ganglion, hyperalgesia and nav1.8
2) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.42 Pain Relevance 1.79
However, discrepancies between these findings and the observed reduction of NaV1.8 protein and mRNA expression in the cell bodies of injured sensory neurons [19], as well as the normal development of neuropathic pain behavior in NaV1.8┬ľnull mice [20,21] continue to raise the question of what role, if any, is played by NaV1.8 in the development of neuropathic pain.
Negative_regulation (reduction) of Transcription (expression) of NaV1 in sensory neurons associated with neuropathic pain
3) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.15 Pain Relevance 0.82

General Comments

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