INT14185

Context Info Confidence 0.35 First Reported 1986 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 5.88 Pain Relevance 0.93

peptidase activity (CPB1) extracellular region (CPB1)

Anatomy Link Frequency blood 1 CPB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 6 99.58 Pain 3 99.16 alcohol 4 97.76 ischemia 6 96.32 Chronic pancreatitis 2 93.28 Inflammation 3 75.92 Bile 5 61.28 Inflammatory response 3 43.56 cytokine 1 27.80 Catecholamine 2 12.20

Disease Link Frequency Relevance Heat Gallstones 2 99.92 Pancreatitis 30 99.84 Adrenal Insufficiency 41 99.12 Pancreatic Cancer 2 97.80 Apoptosis 69 97.56 Hypoxia 2 97.28 Prostate Cancer 2 97.24 Cv Unclassified Under Development 8 96.32 Hypothermia 15 92.16 Stress 4 92.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We studied an elderly population undergoing CPB, and more pronounced RAI was observed in patients over 60 years compared with their younger counterparts.

Regulation (population) of CPB associated with adrenal insufficiency

1) Confidence 0.35 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2867788 Disease Relevance 0.40 Pain Relevance 0

The etiology of the pancreatitis had no influence on the PASP values.

Neg (no) Regulation (influence) of PASP associated with pancreatitis

2) Confidence 0.23 Published 1995 Journal Pancreas Section Abstract Doc Link 7624299 Disease Relevance 0.66 Pain Relevance 0.15

Serum PASP values were analyzed by radioimmunoassay, with a range of normal values between 15 and 111 ng/ml.

Regulation (values) of PASP

3) Confidence 0.23 Published 1995 Journal Pancreas Section Abstract Doc Link 7624299 Disease Relevance 0.55 Pain Relevance 0

PASP values were clearly raised in all patients, except in three cases found to have high salivary-type amylase levels, and one patient with recurrent alcohol pancreatitis.

Regulation (values) of PASP associated with pancreatitis and alcohol

4) Confidence 0.18 Published 1990 Journal Pancreas Section Abstract Doc Link 1688389 Disease Relevance 0.51 Pain Relevance 0.10

PASP values were low in chronic painful pancreatitis (n = 15) and pancreatic cancer (n = 11).

Regulation (values) of PASP associated with pain, pancreatic cancer and pancreatitis

5) Confidence 0.18 Published 1990 Journal Pancreas Section Abstract Doc Link 1688389 Disease Relevance 1.06 Pain Relevance 0.13

The use of CPB was shown to be responsible for alterations in blood flow with consequently intestinal mucosal hypoxia and villous tip ischemia [30], [31].

Regulation (responsible) of CPB in blood associated with hypoxia and ischemia

6) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 1.03 Pain Relevance 0.09

Cooper and colleagues have observed an increased rate of apoptosis in duodenal and myocardial tissue from pigs subjected to deep hypothermic circulatory arrest as compared to normothermic CPB controls [5].

Regulation (controls) of CPB associated with apoptosis

7) Confidence 0.12 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.99 Pain Relevance 0.04

However, normothermia for CPB has emerged as an alternative technique for temperature regulation during CPB [13] that has been associated with a comparable clinical outcome [14,15].

Regulation (regulation) of CPB

8) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1550910 Disease Relevance 0.67 Pain Relevance 0

It seems likely, therefore, that AChE can hydrolyze some of the enkephalin precursors that are sensitive to trypsin and carboxypeptidase B, but the one-step nature of its action suggests a mode of action with fewer restrictions.

Regulation (sensitive) of carboxypeptidase B associated with enkephalin

9) Confidence 0.01 Published 1986 Journal Brain Res. Section Abstract Doc Link 3524746 Disease Relevance 0 Pain Relevance 0.43

General Comments

This test has worked.