INT141863

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.77
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Cav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 12 89.40 High High
IPN 2 86.00 High High
Inflammatory response 1 8.56 Low Low
antagonist 13 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
fluoxetine 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 150 99.96 Very High Very High Very High
Hypertrophy 36 97.32 Very High Very High Very High
Cv Unclassified Under Development 10 89.40 High High
Coronary Artery Disease 2 85.80 High High
Injury 3 84.12 Quite High
Death 2 43.40 Quite Low
INFLAMMATION 8 8.56 Low Low
Disease 8 5.00 Very Low Very Low Very Low
Channelopathies 8 5.00 Very Low Very Low Very Low
Hypoxia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In several animal models of PAH and in patients with severe PAH, reductions in pulmonary Cav-1 expression were apparent.
Negative_regulation (reductions) of Gene_expression (expression) of Cav-1 associated with pulmonary hypertension
1) Confidence 0.49 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.78 Pain Relevance 0
In the present study we demonstrated involvement of ROS in IP-mediated GLUT-4 translocation along with increased expression of caveolin (Cav)-3, phospho (p)-endothelial nitric oxide synthase (eNOS), p-Akt, and decreased expression of Cav-1.
Negative_regulation (decreased) of Gene_expression (expression) of Cav
2) Confidence 0.32 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.50 Pain Relevance 0.29
In the present study we demonstrated involvement of ROS in IP-mediated GLUT-4 translocation along with increased expression of caveolin (Cav)-3, phospho (p)-endothelial nitric oxide synthase (eNOS), p-Akt, and decreased expression of Cav-1.
Negative_regulation (decreased) of Gene_expression (expression) of Cav-1
3) Confidence 0.32 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.49 Pain Relevance 0.29
In contrast, nearly all prior S6 mutations (all in CaV1.2 and CaV2.1) produced decreases in VDI at residues above the putative bundle crossing (Kraus et al., 1998, 2000; Stotz et al., 2000, 2004; Stotz and Zamponi, 2001; Splawski et al., 2004, 2005; Hoda et al., 2005; Hohaus et al., 2005; Raybaud et al., 2006, 2007; Barrett and Tsien, 2008).
Negative_regulation (decreases) of Gene_expression (produced) of CaV1
4) Confidence 0.13 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0

General Comments

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