INT141864

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.27
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 3 100.00 Very High Very High Very High
Bioavailability 11 99.16 Very High Very High Very High
ischemia 7 87.80 High High
IPN 1 83.36 Quite High
Inflammation 14 69.68 Quite High
Kinase C 10 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 95 90.40 High High
Cv Unclassified Under Development 5 87.80 High High
Stress 39 86.40 High High
Diabetes Mellitus 32 84.24 Quite High
Pressure And Volume Under Development 18 82.72 Quite High
Dyslipidemia /

Combined Dyslipidemia

2 81.60 Quite High
Obesity 16 80.48 Quite High
Disease 4 80.28 Quite High
Nicotine Addiction 2 79.76 Quite High
Aging 6 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coimmunoprecipitation demonstrated decreased association of Cav-1/eNOS in the IP group compared with the I/R group.
Negative_regulation (decreased) of eNOS Binding (association) of
1) Confidence 0.39 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.40 Pain Relevance 0.29
In addition, diminished levels of the essential eNOS cofactor, tetrahydrobiopterin, results in uncoupling of eNOS and enhanced O2??
Negative_regulation (diminished) of eNOS Binding (uncoupling) of associated with tetrahydrobiopterin
2) Confidence 0.32 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 1.05 Pain Relevance 0.22
Vascular relaxation is encountered by an activated endothelin (ET-1) system, and an over-activated ETA (endothelin receptor A) may contribute to a decline in eNOS activity, resulting in compromised NO bioavailability.1
Negative_regulation (decline) of eNOS Binding (activity) of associated with bioavailability
3) Confidence 0.24 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.73 Pain Relevance 0.05

General Comments

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