INT141865

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.78
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) plasma membrane (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
soleus 4
Slc2a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 6 97.60 Very High Very High Very High
IPN 1 93.16 High High
Opioid 34 80.44 Quite High
Kinase C 7 76.96 Quite High
tolerance 2 70.40 Quite High
narcan 7 21.56 Low Low
Inflammation 53 20.08 Low Low
medulla 14 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 132 98.96 Very High Very High Very High
Cv Unclassified Under Development 5 97.60 Very High Very High Very High
Body Weight 3 86.96 High High
Coronary Artery Disease 1 67.76 Quite High
Stress 4 67.12 Quite High
Injury 4 66.08 Quite High
Diabetes Complications 2 39.56 Quite Low
Targeted Disruption 5 34.40 Quite Low
INFLAMMATION 55 20.08 Low Low
Cancer 67 18.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that both the mRNA and protein levels of GLUT4 were increased by tetrandrine after repeated injections for 3 days.
Positive_regulation (increased) of Transcription (levels) of GLUT4
1) Confidence 0.45 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.33 Pain Relevance 0.35
Increased mRNA expression of GLUT-4 and Cav-3 was observed after 3 h of reperfusion in the IP group compared with other groups.
Positive_regulation (Increased) of Transcription (expression) of GLUT-4
2) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.46 Pain Relevance 0.29
Andrographolide enhanced the uptake of glucose and the mRNA and protein levels of the glucose transporter subtype 4 (GLUT4) in soleus muscle in STZ-diabetic rats [117].
Positive_regulation (enhanced) of Transcription (levels) of glucose transporter subtype 4 in soleus associated with diabetes mellitus
3) Confidence 0.21 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.00 Pain Relevance 0.11
Andrographolide enhanced the uptake of glucose and the mRNA and protein levels of the glucose transporter subtype 4 (GLUT4) in soleus muscle in STZ-diabetic rats [117].
Positive_regulation (enhanced) of Transcription (levels) of GLUT4 in soleus associated with diabetes mellitus
4) Confidence 0.15 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.00 Pain Relevance 0.11

General Comments

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