INT141865

Context Info Confidence 0.45 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.78 Pain Relevance 0.87

endosome (Slc2a4) plasma membrane (Slc2a4) cytoplasm (Slc2a4)

Anatomy Link Frequency soleus 4 Slc2a4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 6 97.60 IPN 1 93.16 Opioid 34 80.44 Kinase C 7 76.96 tolerance 2 70.40 narcan 7 21.56 Inflammation 53 20.08 medulla 14 5.00 antagonist 8 5.00 metalloproteinase 8 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 132 98.96 Cv Unclassified Under Development 5 97.60 Body Weight 3 86.96 Coronary Artery Disease 1 67.76 Stress 4 67.12 Injury 4 66.08 Diabetes Complications 2 39.56 Targeted Disruption 5 34.40 INFLAMMATION 55 20.08 Cancer 67 18.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that both the mRNA and protein levels of GLUT4 were increased by tetrandrine after repeated injections for 3 days.

Positive_regulation (increased) of Transcription (levels) of GLUT4

1) Confidence 0.45 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.33 Pain Relevance 0.35

Increased mRNA expression of GLUT-4 and Cav-3 was observed after 3 h of reperfusion in the IP group compared with other groups.

Positive_regulation (Increased) of Transcription (expression) of GLUT-4

2) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.46 Pain Relevance 0.29

Andrographolide enhanced the uptake of glucose and the mRNA and protein levels of the glucose transporter subtype 4 (GLUT4) in soleus muscle in STZ-diabetic rats [117].

Positive_regulation (enhanced) of Transcription (levels) of glucose transporter subtype 4 in soleus associated with diabetes mellitus

3) Confidence 0.21 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.00 Pain Relevance 0.11

Andrographolide enhanced the uptake of glucose and the mRNA and protein levels of the glucose transporter subtype 4 (GLUT4) in soleus muscle in STZ-diabetic rats [117].

Positive_regulation (enhanced) of Transcription (levels) of GLUT4 in soleus associated with diabetes mellitus

4) Confidence 0.15 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 1.00 Pain Relevance 0.11

General Comments

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