INT141896

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.58
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SQSTM1) cytosol (SQSTM1) nucleoplasm (SQSTM1)
nucleus (SQSTM1) response to stress (SQSTM1) cytoplasm (SQSTM1)
Anatomy Link Frequency
livers 1
erythrocyte 1
Hepa-1c1c7 1
SQSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 97.08 Very High Very High Very High
Pain 15 94.96 High High
cytokine 2 81.24 Quite High
Nerve growth factor 3 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Gabapentin 2 5.00 Very Low Very Low Very Low
tricyclic antidepressant 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 198 99.48 Very High Very High Very High
Bone Disease 222 98.72 Very High Very High Very High
Diabetes Mellitus 10 98.48 Very High Very High Very High
INFLAMMATION 4 97.08 Very High Very High Very High
Periostitis 2 95.82 Very High Very High Very High
Apoptosis 45 94.72 High High
Necrosis 8 82.20 Quite High
Cancer 22 81.84 Quite High
Parkinson's Disease 2 79.12 Quite High
Syndrome 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family

Mutations of the p62/Sequestosome 1 gene (p62/SQSTM1) account for both sporadic and familial forms of Paget's disease of bone (PDB).

Positive_regulation (mutation) of SQSTM1 associated with bone disease
1) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1297578 Disease Relevance 0.71 Pain Relevance 0
Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family

Mutations of the p62/Sequestosome 1 gene (p62/SQSTM1) account for both sporadic and familial forms of Paget's disease of bone (PDB).

Positive_regulation (mutation) of p62/sequestosome associated with bone disease
2) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1297578 Disease Relevance 0.71 Pain Relevance 0
Exon 8 of the p62/SQSTM1 gene was amplified by PCR (I-Cycler; Bio-Rad Laboratories, Milan, Italy) using a couple of primers located in the flanking intron: 5'-CAGTGTGGCCTGTGAGGAC-3'/5'-CAGTGAGCCTTGGGTCTCG-3'.
Positive_regulation (amplified) of SQSTM1
3) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 0.21 Pain Relevance 0
Notably, the reduction in the basal level of Nrf2 upon siRNA depletion of SQSTM1 did not compromise the inducibility of the Keap1-Nrf2 pathway, as demonstrated by the marked accumulation of Nrf2 in both si-CON and si-SQSTM1 m3-transfected Hepa-1c1c7 cells exposed to iodoacetamide or tert-butylhydroquinone for 1 h (Fig. 3E).
Positive_regulation (accumulation) of si-SQSTM1 in Hepa-1c1c7
4) Confidence 0.37 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
CONTEXT: A middle-aged woman with recent-onset painful swollen fingers and widespread periostitis, elevated serum alkaline phosphatase (ALP) activity and erythrocyte sedimentation rate, and accelerated skeletal turnover was found not to have mutations in the gene sequences for exon 1 of receptor activator of nuclear factor-kappaB (RANK), osteoprotegerin (OPG), or sequestosome-1.
Positive_regulation (activator) of sequestosome-1 in erythrocyte associated with pain and periostitis
5) Confidence 0.02 Published 2007 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 17284635 Disease Relevance 0.25 Pain Relevance 0.09
Finally, the observed upregulation of the 'oxidative phosphorylation' pathway in obese subjects is consistent with a response to increased energy demands in obese subjects.
Positive_regulation (upregulation) of oxidative phosphorylation associated with obesity
6) Confidence 0.01 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 1.80 Pain Relevance 0.09
Our findings are consistent with Takamura et al., who demonstrated an upregulation of oxidative phosphorylation genes in the livers of obese, type 2 diabetic patients compared to non-obese diabetics [43].
Positive_regulation (upregulation) of oxidative phosphorylation in livers associated with diabetes mellitus and obesity
7) Confidence 0.01 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC3014865 Disease Relevance 1.90 Pain Relevance 0.07

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