INT14195

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Context Info
Confidence 0.16
First Reported 1990
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a) signal transduction (Pde2a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Pde2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
5HT 10 99.36 Very High Very High Very High
Clonidine 8 99.00 Very High Very High Very High
antagonist 6 98.00 Very High Very High Very High
agonist 4 94.88 High High
Serotonin 1 75.00 Quite High
Bile 1 73.32 Quite High
ischemia 1 70.08 Quite High
Somatostatin 5 25.00 Low Low
Neuropeptide 3 25.00 Low Low
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Natriuresis 4 97.16 Very High Very High Very High
Reprotox - General 2 3 82.16 Quite High
Cv Unclassified Under Development 1 70.08 Quite High
Coronary Heart Disease 20 47.04 Quite Low
Injury 9 5.00 Very Low Very Low Very Low
Hypertrophy 5 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, various phosphodiesterases regulate cGMP catabolism, including PDE-5A, PDE-6, PDE-9A, PDE-10A, and PDE-11A according to their tissue specificity [21-23].
Localization (catabolism) of cGMP
1) Confidence 0.16 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.34 Pain Relevance 0.04
In the first, the relationship between alpha 2-5HT systems were analyzed by determining if alpha 2-stimulated GH release is mediated by 5HT.
Localization (release) of alpha 2-stimulated associated with 5ht
2) Confidence 0.07 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.79
While CGS19281A (20 mg/kg), SKF64139 (50 mg/kg) and yohimbine (5 mg/kg) inhibited GH secretion, the peripherally active PNMT inhibitor SKF29661 (50 mg/kg) did not.
Localization (secretion) of CGS19281A
3) Confidence 0.05 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.27
These peptide antagonists suppressed duodenal HCO3- secretory response to VIP but did not have any effect on either basal or PGE2-stimulated HCO3- secretion.
Localization (secretion) of PGE2-stimulated associated with antagonist
4) Confidence 0.01 Published 1998 Journal Pharmacol. Res. Section Abstract Doc Link 9990657 Disease Relevance 0 Pain Relevance 0.24

General Comments

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