INT141963

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL, RAMP1) plasma membrane (CALCRL, RAMP1) endosome (CALCRL)
extracellular space (RAMP1) endoplasmic reticulum (CALCRL) lysosome (CALCRL)
CALCRL (Homo sapiens)
RAMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 1 98.88 Very High Very High Very High
Calcitonin gene-related peptide 8 98.36 Very High Very High Very High
Migraine 2 87.60 High High
headache 1 86.88 High High
antagonist 7 79.76 Quite High
agonist 2 75.00 Quite High
Chronic pancreatitis 3 59.60 Quite High
Potency 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 6 89.76 High High
Migraine Disorders 2 87.60 High High
Pancreatic Cancer 7 75.00 Quite High
Hypoxia 3 75.00 Quite High
Pancreatitis 3 59.60 Quite High
Cancer 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The calcitonin receptor-like receptor (CLR) associates with the accessory protein RAMP1 to form a receptor for the neuropeptide calcitonin gene-related peptide (CGRP).
calcitonin receptor-like receptor Binding (associates) of RAMP1 associated with neuropeptide and calcitonin gene-related peptide
1) Confidence 0.43 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20188075 Disease Relevance 0.15 Pain Relevance 0.66
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
CRLR Binding (binding) of RAMP
2) Confidence 0.32 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.66 Pain Relevance 0.12

General Comments

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