INT141965

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.60
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CALCRL) aging (ADM) endoplasmic reticulum (CALCRL)
signal transducer activity (CALCRL) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
plasma 1
ADM (Homo sapiens)
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 96.72 Very High Very High Very High
rheumatoid arthritis 75 78.60 Quite High
cytokine 1 77.20 Quite High
Inflammation 2 72.00 Quite High
Osteoarthritis 27 68.24 Quite High
Chronic pancreatitis 12 54.64 Quite High
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 24 84.80 Quite High
Pheochromocytoma 1 84.12 Quite High
Rheumatoid Arthritis 75 78.60 Quite High
Pancreatic Cancer 28 75.00 Quite High
Hypoxia 12 75.00 Quite High
Adhesions 75 73.44 Quite High
INFLAMMATION 2 72.00 Quite High
Disease 2 70.96 Quite High
Systemic Lupus Erythematosus 1 70.16 Quite High
Systemic Sclerosis 1 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
ADM Binding (binding) of calcitonin receptor-like receptor
1) Confidence 0.33 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.62 Pain Relevance 0.11
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
Adrenomedullin Binding (binding) of calcitonin receptor-like receptor
2) Confidence 0.33 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.62 Pain Relevance 0.11
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
ADM Binding (binding) of CRLR
3) Confidence 0.33 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.62 Pain Relevance 0.11
Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor-like receptor (CRLR) and members of the receptor activity-modifying protein (RAMP) family.
Adrenomedullin Binding (binding) of CRLR
4) Confidence 0.33 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.62 Pain Relevance 0.11
In FLSs, adrenomedullin binds to a heterodimeric plasma membrane receptor composed of the seven-transmembrane domain protein calcitonin receptor-like receptor (CLR) coupled to one of two receptor activity-modifying proteins (RAMP-2 or -3) [9].
adrenomedullin Binding (binds) of calcitonin receptor-like receptor in plasma
5) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.11 Pain Relevance 0.46

General Comments

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