INT141967

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.35
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (RAMP3) signal transduction (RAMP3) plasma membrane (RAMP3)
lysosome (RAMP3)
RAMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 66 99.60 Very High Very High Very High
Chronic pancreatitis 6 93.72 High High
trigeminal ganglion 13 84.40 Quite High
medulla 2 83.08 Quite High
Migraine 42 79.32 Quite High
Sumatriptan 10 74.80 Quite High
antagonist 11 71.00 Quite High
Triptan 28 63.92 Quite High
qutenza 2 61.32 Quite High
Inflammation 2 59.52 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 14 99.84 Very High Very High Very High
Adenocarcinoma 12 95.64 Very High Very High Very High
Hypoxia 6 94.32 High High
Pancreatitis 6 93.72 High High
Ganglion Cysts 13 84.40 Quite High
Headache 50 79.32 Quite High
Cancer 2 64.08 Quite High
Neurogenic Inflammation 1 60.40 Quite High
Increased Venous Pressure Under Development 9 56.88 Quite High
Gastroparesis 2 55.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By immunohistochemistry, ADM, CRLR, RAMP1 and RAMP2, but not RAMP3, were expressed in pancreatic cancer cells.
Gene_expression (expressed) of RAMP3 associated with pancreatic cancer
1) Confidence 0.69 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.13 Pain Relevance 0.25
All 5 evaluated pancreatic cancer cells lines expressed ADM, CRLR, RAMP1 and RAMP2, whereas RAMP3 was expressed in only 1/5 pancreatic cancer cell lines.
Gene_expression (expressed) of RAMP3 associated with pancreatic cancer
2) Confidence 0.69 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.62 Pain Relevance 0.27
Co-expression of CLR with RAMP1 composes the CGRP receptor, while co-expression of CLR with either RAMP2 or RAMP3 represents the adrenomedullin (AM) receptor or possibly a combined receptor (CGRP and AM).
Gene_expression (expression) of RAMP3 associated with calcitonin gene-related peptide
3) Confidence 0.46 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.60 Pain Relevance 1.17
Likewise, expression of the calcitonin receptor (CALCR) gene with RAMP2 results in a receptor responding most potently to calcitonin, expression of CALCR with RAMP3 results in a receptor responding to both calcitonin and the pancreatic hormone amylin; and expression of CALCR with RAMP1 promoted the formation of a receptor responding most potently to amylin and CGRP [24].
Gene_expression (expression) of RAMP3
4) Confidence 0.26 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox