INT141968

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 11.19
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
neuron 1
heart 1
cortex 1
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 32 99.84 Very High Very High Very High
Chronic pancreatitis 15 97.96 Very High Very High Very High
rheumatoid arthritis 302 96.24 Very High Very High Very High
Osteoarthritis 108 34.48 Quite Low
Action potential 8 31.20 Quite Low
Inflammation 20 22.80 Low Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
Angina 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 300 100.00 Very High Very High Very High
Hypoxia 15 100.00 Very High Very High Very High
Myocardial Infarction 172 99.96 Very High Very High Very High
Pancreatic Cancer 35 99.96 Very High Very High Very High
Adenocarcinoma 30 99.84 Very High Very High Very High
Death 50 99.16 Very High Very High Very High
Pancreatitis 15 97.96 Very High Very High Very High
Cancer 17 96.80 Very High Very High Very High
Rheumatoid Arthritis 302 96.24 Very High Very High Very High
Ganglion Cysts 8 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion.
Positive_regulation (induced) of Adrenomedullin associated with hypoxia and pancreatic cancer
1) Confidence 0.65 Published 2007 Journal Int. J. Cancer Section Title Doc Link 17290391 Disease Relevance 1.03 Pain Relevance 0.20
In conclusion, ADM is induced by hypoxia and over-expressed in PDAC and might therefore serve as a potential tumor marker.
Positive_regulation (induced) of ADM associated with adenocarcinoma, cancer and hypoxia
2) Confidence 0.57 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.59 Pain Relevance 0.22
Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion.
Positive_regulation (enhances) of Adrenomedullin associated with hypoxia and pancreatic cancer
3) Confidence 0.47 Published 2007 Journal Int. J. Cancer Section Title Doc Link 17290391 Disease Relevance 1.09 Pain Relevance 0.20
The receptor antagonist (22-52)adrenomedullin inhibits adrenomedullin-related integrin activation
Positive_regulation (activation) of adrenomedullin-related associated with antagonist
4) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.48 Pain Relevance 0.20
The receptor antagonist (22-52)adrenomedullin inhibits adrenomedullin-related integrin activation
Positive_regulation (activation) of adrenomedullin associated with antagonist
5) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.54 Pain Relevance 0.20
Immunoblotting showed that adrenomedullin increased the talin-?
Positive_regulation (increased) of adrenomedullin
6) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.57 Pain Relevance 0.19
Adrenomedullin-enhanced rheumatoid FLSs adhesion is linked to integrin activation
Positive_regulation (linked) of Adrenomedullin associated with adhesions
7) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.29 Pain Relevance 0.25
ADM serum levels were significantly increased in PDAC patients compared to healthy controls and chronic pancreatitis (CP) patients, with an area under the ROC curve of 0.83 and 0.98, respectively.
Positive_regulation (increased) of ADM associated with adenocarcinoma and chronic pancreatitis
8) Confidence 0.38 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.23 Pain Relevance 0.28
ADM was strongly induced by hypoxia and significantly increased invasiveness in 3/5 human pancreatic cancer cells.
Positive_regulation (induced) of ADM associated with hypoxia and pancreatic cancer
9) Confidence 0.38 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.63 Pain Relevance 0.26
MRproADM is very similar to NTproBNP, it is higher in females than males, and is increased with age.


Positive_regulation (increased) of MRproADM
10) Confidence 0.25 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.70 Pain Relevance 0
However, a recent study using the more stable MRproADM has shown that post AMI, increased MRproADM was associated with death, heart failure or both at one year, over and above information gained from NTproBNP alone [78].
Positive_regulation (increased) of MRproADM in heart associated with death and myocardial infarction
11) Confidence 0.25 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.88 Pain Relevance 0
A sequence of stationary images which induce AM can be presented over a short-range (less than a degree of the visual field) or over a longer range (several degrees).
Positive_regulation (induce) of AM
12) Confidence 0.03 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0.07 Pain Relevance 0
The consistency, timing, direction and constant speed of the evoked membrane potential dynamics of the neuron populations in areas 17, 18, 19, and 21 suggest that the motion feedback and depolarization wave-fronts may play a role in inducing AM.
Positive_regulation (inducing) of AM in neuron
13) Confidence 0.03 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
If AM is always dependent on the visual cortex computing an activation wave-front from the retinotopic site of one stimulus to the next, a stimulation in which 1 square is followed by 2 oppositely positioned squares (experiment 4; Fig. 1E), should produce 2 wave-fronts, each traveling in opposite directions but toward the retinotopic sites of the 2 new squares.
Positive_regulation (dependent) of AM in cortex
14) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
The wave-fronts appear to correspond to the time interval eliciting AM and to the predicted speed of the AM (Supplementary Video 1; Giaschi and Anstis 1989; Chavane et al. 2000).
Positive_regulation (eliciting) of AM
15) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0.08 Pain Relevance 0

General Comments

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