INT141969

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.07
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
spike 4
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 75 100.00 Very High Very High Very High
Osteoarthritis 27 100.00 Very High Very High Very High
Arthritis 2 98.76 Very High Very High Very High
antagonist 8 82.16 Quite High
Chronic pancreatitis 3 78.76 Quite High
Action potential 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 75 100.00 Very High Very High Very High
Rheumatoid Arthritis 75 100.00 Very High Very High Very High
Osteoarthritis 27 100.00 Very High Very High Very High
Hypoxia 3 100.00 Very High Very High Very High
Adenocarcinoma 6 99.84 Very High Very High Very High
Seronegative Spondarthritis 1 98.76 Very High Very High Very High
Cancer 4 98.00 Very High Very High Very High
Pancreatic Cancer 7 94.92 High High
Pancreatitis 3 78.76 Quite High
Paralysis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, ADM is induced by hypoxia and over-expressed in PDAC and might therefore serve as a potential tumor marker.
Positive_regulation (induced) of Gene_expression (expressed) of ADM associated with adenocarcinoma, cancer and hypoxia
1) Confidence 0.57 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.59 Pain Relevance 0.22
We found that adrenomedullin specifically increased RA-FLS adhesion to ECM proteins but had no effect on OA-FLS adhesion.
Positive_regulation (increased) of Gene_expression (adhesion) of adrenomedullin associated with rheumatoid arthritis, osteoarthritis and adhesions
2) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 2.48 Pain Relevance 0.98
Moreover, 21 of the 37 units had a mean spike rate in the AM condition which was significantly and positively correlated to the averaged ?
Positive_regulation (was) of Gene_expression (condition) of AM in spike
3) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
Moreover, 21 of the 37 units had a mean spike rate in the AM condition which was significantly and positively correlated to the averaged ?
Positive_regulation (correlated) of Gene_expression (condition) of AM in spike
4) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0

General Comments

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