INT14197

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a, Gh1) signal transduction (Pde2a, Gh1) nucleus (Pde2a, Gh1)
plasma membrane (Pde2a, Gh1) mitochondrion (Gh1) Golgi apparatus (Pde2a)
Anatomy Link Frequency
arcuate nucleus 2
Pde2a (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 8 100.00 Very High Very High Very High
5HT 10 99.52 Very High Very High Very High
Serotonin 1 75.00 Quite High
Somatostatin 5 66.96 Quite High
antagonist 1 61.08 Quite High
agonist 2 58.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that an intact 5HT system is required for alpha 2-stimulated GH release. 5,7-DHT neurotoxin microinjected into the midline arcuate nucleus (6 micrograms/mg,iv) or bilaterally into the ventromedial nucleus or perifornical area (4 micrograms/0.2 microliter) 5 days previously suppressed the CLON (30 micrograms/kg)-induced GH surge only in animals with arcurate nucleus lesions.
alpha 2-stimulated Positive_regulation (stimulated) of Localization (release) of GH in arcuate nucleus associated with 5ht and clonidine
1) Confidence 0.04 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.82
These results suggest that CGS19281A has an in vivo inhibitory effect on the clonidine induced GH secretion.
CGS19281A Positive_regulation (induced) of Localization (secretion) of GH associated with clonidine
2) Confidence 0.03 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.26

General Comments

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