INT14199

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Context Info
Confidence 0.05
First Reported 1990
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GNRH1, Gh1) signal transduction (GNRH1, Gh1) extracellular region (GNRH1, Gh1)
mitochondrion (Gh1) cell-cell signaling (GNRH1) cytosol (Gh1)
Anatomy Link Frequency
anterior pituitary 2
GNRH1 (Homo sapiens)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
5HT 10 100.00 Very High Very High Very High
tetrodotoxin 6 99.72 Very High Very High Very High
Somatostatin 5 97.92 Very High Very High Very High
Clonidine 5 81.92 Quite High
sodium channel 2 75.00 Quite High
Serotonin 1 75.00 Quite High
antagonist 1 32.96 Quite Low
agonist 2 30.28 Quite Low
Neuropeptide 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tetrodotoxin (TTX) blunted the GH release induced by PACAP-38 but not by GRH.
GRH Neg (not) Positive_regulation (induced) of Localization (release) of GH associated with tetrodotoxin
1) Confidence 0.05 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533816 Disease Relevance 0 Pain Relevance 0.32
Both pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and growth hormone-releasing hormone (GRH) stimulated growth hormone (GH) release from perfused rat anterior pituitary cells.
GRH Positive_regulation (stimulated) of Localization (release) of GH in anterior pituitary
2) Confidence 0.05 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533816 Disease Relevance 0 Pain Relevance 0.31
Inasmuch as anti-SRIF failed to reverse the 5,7-DHT suppression of GH secretion, the results of this experiment suggest that GRH mediates NE-5HT-induced GH secretion.
GRH Positive_regulation (mediates) of Localization (secretion) of GH associated with 5ht and somatostatin
3) Confidence 0.02 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.49

General Comments

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