INT142005

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.53
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL18A1) extracellular region (COL18A1) cell adhesion (COL18A1)
structural molecule activity (COL18A1)
Anatomy Link Frequency
sputum 1
tendons 1
vessels 1
COL18A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 93.56 High High
antagonist 3 92.04 High High
Potency 3 87.68 High High
Angina 4 81.40 Quite High
metalloproteinase 17 74.00 Quite High
Glutamate 1 51.28 Quite High
agonist 45 51.24 Quite High
nMDA receptor 1 50.48 Quite High
substance P 3 41.52 Quite Low
chemokine 7 23.00 Low Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 53 99.30 Very High Very High Very High
Asthma 57 98.64 Very High Very High Very High
Coronary Artery Disease 19 98.08 Very High Very High Very High
Pathologic Constriction 4 97.00 Very High Very High Very High
Disease 30 94.40 High High
Myeloid Leukemia 6 92.40 High High
Apoptosis 43 91.00 High High
Cancer 317 89.60 High High
Melanoma 17 86.12 High High
Leukemia 15 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The angiogenic activity of MM ECs correlates with downregulated expression of the endogenous antiangiogenic factor, endostatin [169].
Gene_expression (expression) of endostatin associated with multiple myeloma
1) Confidence 0.75 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.34 Pain Relevance 0.07
In conclusion, endostatin is suggested to be produced from the coronary circulation in patients with CHD and may play an important role in the regulation of the growth of coronary collateral vessels.
Gene_expression (produced) of endostatin in vessels associated with coronary artery disease
2) Confidence 0.68 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17293192 Disease Relevance 0.98 Pain Relevance 0.14
In addition, endostatin production within the coronary circulation was higher in patients with poorly developed collaterals than in those with well-developed collaterals.
Gene_expression (production) of endostatin
3) Confidence 0.46 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17293192 Disease Relevance 0.96 Pain Relevance 0.16
In adult tendons, the anti-angiogenesis factor endostatin is expressed [22] – especially in the gliding area of gliding tendons.
Gene_expression (expressed) of endostatin in tendons
4) Confidence 0.46 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.08 Pain Relevance 0.09
Interestingly, an imbalance between VEGF and endostatin levels was found in induced sputum from asthmatic patients [28].
Gene_expression (levels) of endostatin in sputum associated with asthma
5) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.48 Pain Relevance 0.15
Several lessons learned from early clinical trials in antiangiogenic therapy would seem to support a role for antiangiogenic gene transfer strategies in the future.
Gene_expression (transfer) of antiangiogenic gene
6) Confidence 0.12 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.69 Pain Relevance 0

General Comments

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