INT14201

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Context Info
Confidence 0.81
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.29
Pain Relevance 3.36

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Anatomy Link Frequency
B cells 2
nerves 1
GALT 1
brain 1
plaque 1
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 14 99.72 Very High Very High Very High
Opioid 9 98.32 Very High Very High Very High
opioid receptor 3 96.68 Very High Very High Very High
Catecholamine 1 96.24 Very High Very High Very High
substance P 8 96.08 Very High Very High Very High
Neuritis 7 95.76 Very High Very High Very High
anesthesia 1 92.48 High High
Kappa opioid receptor 3 90.44 High High
Neuropeptide 1 88.48 High High
antagonist 5 87.68 High High
Disease Link Frequency Relevance Heat
Multiple Myeloma 5 97.72 Very High Very High Very High
Body Weight 1 96.76 Very High Very High Very High
Experimental Autoimmune Neuritis 7 95.76 Very High Very High Very High
Cancer 10 93.96 High High
Hypercalcemia 1 93.16 High High
Htlv Types I And Ii 1 91.64 High High
B-cell Chronic Lymphocytic Leukemia 9 90.64 High High
Syndrome 3 90.28 High High
Immunization 1 87.60 High High
Lymphatic System Cancer 19 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of capsaicin treatment on immunoglobulin secretion in the rat: further evidence for involvement of tachykinin-containing afferent nerves.
Localization (secretion) of immunoglobulin in nerves associated with qutenza
1) Confidence 0.81 Published 1990 Journal J. Neuroimmunol. Section Title Doc Link 1688877 Disease Relevance 0 Pain Relevance 0.73
At days 5, 6 and 7 of the response, there was a statistically significant decrease in the number of plaque-forming cells secreting antigen-specific IgM, an effect not observed in capsaicin-pretreated rats which were given a subcutaneous infusion of substance P at the time of antigen injection.
Localization (secreting) of IgM in plaque associated with qutenza and substance p
2) Confidence 0.81 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 1688877 Disease Relevance 0 Pain Relevance 0.68
The cell line OR-689.2.4 secreted an IgM that was capable of partially inhibiting opioid binding to rat neural membranes under equilibrium binding conditions, while not affecting the binding of nonopioid ligands.
Localization (secreted) of IgM in neural associated with opioid
3) Confidence 0.80 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2999128 Disease Relevance 0 Pain Relevance 0.54
Lewis rats were immunized with bovine peripheral nerve myelin (BPM), and levels of B cells secreting IgM and IgG antibodies to BPM, P2 and P0, the glycolipid GM1 and five peptides of myelin-associated glycoprotein (MAG) were determined.
Localization (ecreting ) of IgM in B cells
4) Confidence 0.20 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7528788 Disease Relevance 1.07 Pain Relevance 0.60
We examined whether autoradiographic localization of [125I]-antirabbit immunoglobulin (IgG) was suitable for light and electron microscopic detection of a rabbit antiserum to the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), and whether autoradiographic and peroxidase labeling could be combined for simultaneous immunocytochemical identification of TH and neuropeptides in brain.
Spec (whether) Localization (localization) of immunoglobulin in brain associated with catecholamine and neuropeptide
5) Confidence 0.06 Published 1986 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2422251 Disease Relevance 0 Pain Relevance 0.09
Organized gut-associated lymphoid tissue (GALT) populations, intestinal secretion, mucosal and serum immunoglobulin concentrations, and neutrophil infiltration were studied.
Localization (secretion) of immunoglobulin in GALT
6) Confidence 0.05 Published 2004 Journal J. Nutr. Section Abstract Doc Link 15465764 Disease Relevance 0.10 Pain Relevance 0.09
Conventional cytogenetic analysis demonstrates a translocation between the immunoglobulin heavy chain and cyclin D1 (CCND1, BCL1 and PRAD1) genes, t(11;14)(q13;q32) in 70% to 75% of cases.
Localization (translocation) of immunoglobulin
7) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2853553 Disease Relevance 1.27 Pain Relevance 0
The cell line KA8 secretes an IgG1 (kappa-light chain) immunoglobulin.
Localization (secretes) of immunoglobulin
8) Confidence 0.01 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851205 Disease Relevance 0 Pain Relevance 0.50
The demonstration of increased osteoclast activating factor (OAF) derived from the cultured myeloma cells from each case suggests that the secretion of OAF and immunoglobulin are unrelated.
Localization (secretion) of immunoglobulin in osteoclast
9) Confidence 0.01 Published 1986 Journal Am. J. Med. Sci. Section Abstract Doc Link 3518452 Disease Relevance 0.40 Pain Relevance 0.08
B-cell functional deficits as well as radioresistant T-helper and radiosensitive T-suppressor function assessed in a pokeweed mitogen-driven immunoglobulin secretion assay appeared unaffected by IFN administration.
Localization (secretion) of immunoglobulin in B-cell
10) Confidence 0.00 Published 1983 Journal J Biol Response Mod Section Abstract Doc Link 6607323 Disease Relevance 0.45 Pain Relevance 0.05

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