INT142025

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.24
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
neuron 4
cleavage 2
Bid (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 11 99.42 Very High Very High Very High
imagery 22 97.02 Very High Very High Very High
Glutamate receptor 66 96.56 Very High Very High Very High
cytokine 11 78.20 Quite High
tetrodotoxin 22 76.16 Quite High
agonist 22 74.32 Quite High
Glutamate 11 58.72 Quite High
Angina 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 352 99.78 Very High Very High Very High
Death 473 99.40 Very High Very High Very High
Aids-related Complex 3 96.56 Very High Very High Very High
Cv General 4 Under Development 11 88.44 High High
Injury 55 87.44 High High
Cancer 13 84.40 Quite High
Necrosis 11 83.92 Quite High
Hypoxia 22 74.08 Quite High
Sprains And Strains 2 65.20 Quite High
Neurodegenerative Disease 11 60.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How may NMDA receptor overactivation stimulate FL-Bid translocation?
Localization (translocation) of Bid associated with nmda receptor
1) Confidence 0.69 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.67 Pain Relevance 0.05
Immunoblotting with the Bid antibody revealed that p21 FL-Bid translocated from the cytosol to the mitochondria-containing pellet fraction 4 h and more pronounced 8 h after termination of the NMDA exposure (Fig. 2A).
Localization (translocated) of p21 FL-Bid
2) Confidence 0.69 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.14 Pain Relevance 0
The ability of both tBid and FL-Bid to translocate to mitochondria and to induce cell death suggest that this BH3-only protein is a central mediator of pathophysiological neuron death.


Localization (translocate) of tBid in neuron associated with death
3) Confidence 0.69 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.59 Pain Relevance 0.10
CEBS2 and BID are released, and can be accessed at http://cebs.niehs.nih.gov and https://dir-apps.niehs.nih.gov/arc/.
Localization (released) of BID associated with aids-related complex
4) Confidence 0.68 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2238989 Disease Relevance 0.16 Pain Relevance 0
Translocation of FL-Bid to mitochondria during excitotoxic neuron death
Localization (Translocation) of Bid in neuron associated with death
5) Confidence 0.64 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.24 Pain Relevance 0
Changes in the intracellular phospholipid environment during excitotoxic cell death signals may hence induce the translocation of FL-Bid to mitochondria and may initiate the release of pro-apoptotic factors from mitochondria.


Localization (translocation) of Bid associated with apoptosis and death
6) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.63 Pain Relevance 0.03
Our data suggest that translocation of FL-Bid is sufficient for the activation of mitochondrial cell death pathways in response to glutamate receptor overactivation.



Localization (translocation) of Bid associated with glutamate receptor and death
7) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Abstract Doc Link PMC1808451 Disease Relevance 0.76 Pain Relevance 0.15
The ability of both tBid and FL-Bid to translocate to mitochondria and to induce cell death suggest that this BH3-only protein is a central mediator of pathophysiological neuron death.


Localization (translocate) of Bid in neuron associated with death
8) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.59 Pain Relevance 0.10
Instead, we observed an efficient translocation of FL-Bid to mitochondria during excitotoxic neuron death.
Localization (translocation) of Bid in neuron associated with death
9) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.22 Pain Relevance 0.09
Using a fluorescence resonance energy transfer single-cell imaging approach of Bid cleavage and translocation during apoptosis, we have recently demonstrated that caspase-independent excitotoxic apoptosis induces a translocation of full length Bid (FL-Bid) from the cytosol to mitochondria [28].
Localization (translocation) of Bid in cleavage associated with apoptosis and imagery
10) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.22 Pain Relevance 0.14
A previous report has demonstrated that translocation of FL-Bid to mitochondria may also occur in response to an activation of death receptors when caspase-8 activation is blocked by the addition of a caspase-8 inhibitor [43].
Localization (translocation) of Bid associated with death
11) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.76 Pain Relevance 0.03
Using a fluorescence resonance energy transfer single-cell imaging approach of Bid cleavage and translocation during apoptosis, we have recently demonstrated that caspase-independent excitotoxic apoptosis induces a translocation of full length Bid (FL-Bid) from the cytosol to mitochondria [28].
Localization (translocation) of Bid in cleavage associated with apoptosis and imagery
12) Confidence 0.60 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.21 Pain Relevance 0.14
Placebo-controlled clinical studies performed to date have found that sustained-release ranolazine 500 to 1500 mg PO BID was associated with significantly increased time to onset of angina (range of increase, 27.0-144.0 s; P < 0.05 [varied among studies]), exercise duration (range of increase, 23.8-99.0 s; P < 0.05 [varied among studies] ), and time to 1-mm ST depression (range of increase, 27.6-146.2 s; P < 0.05 [varied among studies]).
Localization (release) of BID
13) Confidence 0.41 Published 2006 Journal Clin Ther Section Body Doc Link 17296457 Disease Relevance 0.05 Pain Relevance 0

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