INT14204

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Context Info
Confidence 0.96
First Reported 1989
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 20.94
Pain Relevance 11.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 3
brain 3
liver 1
vascular endothelium 1
upper respiratory tract 1
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 252 100.00 Very High Very High Very High
substance P 52 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
Neuropeptide 8 100.00 Very High Very High Very High
adenocard 13 99.16 Very High Very High Very High
potassium channel 3 98.48 Very High Very High Very High
antagonist 111 98.36 Very High Very High Very High
Catecholamine 7 96.44 Very High Very High Very High
metalloproteinase 36 94.20 High High
Inflammation 90 91.68 High High
Disease Link Frequency Relevance Heat
Hypotension 16 100.00 Very High Very High Very High
Anaphylaxis 3 99.80 Very High Very High Very High
Natriuresis 19 99.64 Very High Very High Very High
Pressure And Volume Under Development 64 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 143 99.32 Very High Very High Very High
Apoptosis 91 98.72 Very High Very High Very High
Cough 145 98.68 Very High Very High Very High
Hereditary Angioedema 61 98.64 Very High Very High Very High
Stress 66 97.80 Very High Very High Very High
Atherosclerosis 109 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proteolysis of bradykinin, [Leu5]enkephalin and some of its synthetic analogs.
Protein_catabolism (proteolysis) of bradykinin associated with enkephalin and bradykinin
1) Confidence 0.96 Published 1989 Journal Biokhimiia Section Abstract Doc Link 2804171 Disease Relevance 0 Pain Relevance 0.24
We identified two elements of this system, namely kininogen-1 and N-carboxypeptidase, which is a zinc metalloprotease that degrades bradykinin and anaphylactic peptides of the complement system [65].
Protein_catabolism (degrades) of bradykinin associated with anaphylaxis and bradykinin
2) Confidence 0.96 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906814 Disease Relevance 0.84 Pain Relevance 0.37
Alternatively, application of HK fragments D3 or light chain, which compete with uncleaved HK for cell binding, promote kininogen proteolysis and bradykinin release.
Protein_catabolism (proteolysis) of bradykinin associated with bradykinin
3) Confidence 0.90 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.28 Pain Relevance 0.54
Furthermore, ACE degrades bradykinin, substance P, enkephalins and some of the reproductive peptide hormones.
Protein_catabolism (degrades) of bradykinin associated with enkephalin, bradykinin and substance p
4) Confidence 0.64 Published 2001 Journal Acta Derm. Venereol. Section Abstract Doc Link 11800136 Disease Relevance 0.65 Pain Relevance 0.28
However, a significantly attenuated adrenergic responsiveness associated with incomplete blockade of the plasma renin-angiotensin system supports the hypothesis that inhibition of angiotensin II generation and of bradykinin degradation within the vascular wall mediates some of the vasodilatory effects of ACE inhibitors.


Protein_catabolism (degradation) of bradykinin in plasma
5) Confidence 0.64 Published 1996 Journal Anesthesiology Section Body Doc Link 8638832 Disease Relevance 0 Pain Relevance 0
In animal models, ACE-I can retard the development of atherosclerosis, and these antiatherogenic properties can be related to the inhibition of angiotensin-II (Ang II) formation and to the inhibition of bradykinin degradation, which promotes vasodilatation by stimulating the production of arachidonic acid metabolites and nitric oxide (NO) in vascular endothelium.
Protein_catabolism (degradation) of bradykinin in vascular endothelium associated with atherosclerosis, increased venous pressure under development and bradykinin
6) Confidence 0.62 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.98 Pain Relevance 0.19
ACE-I alter this balance by decreasing the formation of Ang II and the degradation of bradykinin (Figure 1): the bradykinin is potentiated and NO is released to a greater extent, resulting in decreased migration and proliferation of vascular smooth muscle cells, decreased accumulation and activation of inflammatory cells, decreased oxidative stress, and improved endothelial function.


Protein_catabolism (degradation) of bradykinin in smooth muscle cells associated with stress, inflammation and bradykinin
7) Confidence 0.62 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.86 Pain Relevance 0.24
In plasma samples taken throughout her pregnancy, before, during, and after clinical attacks of angioedema, all of her plasma HMWK was shown to be cleaved into the 45 kd light chain form.
Protein_catabolism (cleaved) of HMWK in plasma associated with pressure and volume under development
8) Confidence 0.60 Published 1990 Journal J. Lab. Clin. Med. Section Abstract Doc Link 1688910 Disease Relevance 0.55 Pain Relevance 0.08
The method was applied to the determination of enkephalins in rat brain and to a degradation study of bradykinin in human plasma.
Protein_catabolism (degradation) of bradykinin in plasma associated with enkephalin and bradykinin
9) Confidence 0.47 Published 1997 Journal J Chromatogr A Section Abstract Doc Link 9129312 Disease Relevance 0 Pain Relevance 0.38
A liver metalloendopeptidase which degrades the circulating hypotensive peptide hormones bradykinin and atrial natriuretic peptide.
Protein_catabolism (degrades) of bradykinin in liver associated with natriuresis, hypotension and bradykinin
10) Confidence 0.47 Published 1999 Journal Braz. J. Med. Biol. Res. Section Title Doc Link 10347768 Disease Relevance 0.35 Pain Relevance 0.21
ACE-I also promote the degradation of bradykinin and the release of nitric oxide, a potent vasodilator; further, thay have shown important implications for vascular oxidative stress.
Protein_catabolism (degradation) of bradykinin associated with stress and bradykinin
11) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2663435 Disease Relevance 0.73 Pain Relevance 0.09
The kinetic parameters displayed by human endopeptidase 3.4.24.16 towards a series of natural neuropeptides indicated that bradykinin was the most efficiently proteolysed.
Protein_catabolism (proteolysed) of bradykinin associated with neuropeptide and bradykinin
12) Confidence 0.38 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.24
NEP and NEP2 participate in degradation of other peptides, such as angiotensin-1, bradykinin and enkephalins which are also implicated in sperm cell function [27,28] and might thus be relevant to explain the tachykinin antagonist-resistant component of the response to phosphoramidon.
Protein_catabolism (degradation) of bradykinin in sperm cell associated with antagonist, enkephalin and bradykinin
13) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.05 Pain Relevance 0.49
Neutral endopeptidase (NEP), a membrane-bound metallopeptidase enzyme that degrades neuropeptides, bradykinin, atrial natriuretic factor, enkephalins, and endothelin may regulate response to injury.
Protein_catabolism (degrades) of bradykinin associated with natriuresis, injury, neuropeptide, enkephalin and bradykinin
14) Confidence 0.35 Published 2003 Journal Shock Section Abstract Doc Link 12785004 Disease Relevance 0.67 Pain Relevance 0.20
Adenosine, acadesine, ACE inhibitors which prevent bradykinin degradation, nicorandil, and others have been used in clinical studies.
Protein_catabolism (degradation) of bradykinin associated with adenocard and bradykinin
15) Confidence 0.24 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.47 Pain Relevance 0.37
The decreased perfusion pressure provoked by low dose bradykinin is potentiated by captopril (which blocks bradykinin degradation) and is attenuated with the B2-receptor antagonist HOE-140 or by pretreatment with an inhibitor of nitric oxide synthase.
Protein_catabolism (degradation) of bradykinin associated with antagonist and bradykinin
16) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.14 Pain Relevance 0.23
Inhibition of bradykinin degradation by ACE inhibitors may increase the activity of superoxide dismutase and modulate the production of nitric oxide, leading to the inactivation of reactive oxygen species, while also inhibiting various pro-oxidative mechanisms within the vasculature (Ehring et al 1994).
Protein_catabolism (degradation) of bradykinin in vasculature associated with bradykinin
17) Confidence 0.20 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.38 Pain Relevance 0.60
As a kininase, this enzyme is responsible for the degradation of bradykinin.
Protein_catabolism (degradation) of bradykinin associated with bradykinin
18) Confidence 0.20 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.59 Pain Relevance 0.58
Bradykinin is a vasodilating nonapeptide that is degraded by ACE (Hornig and Drexler 1997).
Protein_catabolism (degraded) of Bradykinin associated with bradykinin
19) Confidence 0.20 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.53 Pain Relevance 0.47
Angiotensin-converting enzyme inhibitors (ACEIs), by reducing the production of angiotensin II and possibly by blocking the degradation of bradykinin, exert many biological effects that lead to improvement in symptoms, fewer admissions to the hospital, and prolonged survival in HF; as a consequence, they are recommended for all patients with systolic dysfunction.
Protein_catabolism (degradation) of bradykinin associated with bradykinin and myocardial infarction
20) Confidence 0.18 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948383 Disease Relevance 1.38 Pain Relevance 0.11

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