INT142049

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.73
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mthfr (Rattus norvegicus)
Mthfr - C677T (1)
Pain Link Frequency Relevance Heat
Migraine 20 98.70 Very High Very High Very High
anesthesia 5 98.28 Very High Very High Very High
Inflammation 5 66.36 Quite High
Restless leg syndrome 11 17.00 Low Low
Piles 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 15 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 4 99.26 Very High Very High Very High
Peripheral Arterial Disease 60 98.96 Very High Very High Very High
Headache 13 98.70 Very High Very High Very High
Migraine Without Aura 2 97.96 Very High Very High Very High
Congenital Anomalies 2 97.96 Very High Very High Very High
Diabetes Mellitus 30 97.88 Very High Very High Very High
Crohn's Disease 13 97.12 Very High Very High Very High
Genetic Predisposition To Disease 1 96.96 Very High Very High Very High
Migraine With Aura 5 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.
Regulation (responsible) of MTHFR (C677T) associated with migraine and genetic predisposition to disease
1) Confidence 0.41 Published 2008 Journal Dis. Markers Section Abstract Doc Link 18957721 Disease Relevance 0.76 Pain Relevance 0.66
Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia.
Regulation (Influence) of methylenetetrahydrofolate reductase associated with anesthesia
2) Confidence 0.39 Published 2008 Journal Anesthesiology Section Title Doc Link 18580170 Disease Relevance 0 Pain Relevance 0.27
Thus the objective of this study was to investigate a possible role for the MTHFR 677C>T polymorphism with PAD (ABI) in subjects with type 2 diabetes.


Spec (possible) Regulation (role) of MTHFR associated with diabetes mellitus and peripheral arterial disease
3) Confidence 0.35 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 1.38 Pain Relevance 0
Influence of MTHFR genotype on contingent negative variation and MRI abnormalities in migraine.
Regulation (Influence) of MTHFR associated with congenital anomalies and migraine
4) Confidence 0.33 Published 2007 Journal Headache Section Title Doc Link 17300365 Disease Relevance 0.38 Pain Relevance 0.37
The influence of MTHFR, MTR, MTRR and TCN2 polymorphisms on the primary and secondary risk of ulcerative colitis have never been evaluated in a same sample population.
Regulation (influence) of MTHFR associated with crohn's disease
5) Confidence 0.32 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 1.09 Pain Relevance 0.06
Genetic polymorphisms affecting methylentetrahydrofolate reductase (MTHFR) activity may influence hematological and neurological dysfunction in cobalamin-deficient patients.
Regulation (affecting) of MTHFR associated with anesthesia
6) Confidence 0.20 Published 2009 Journal Biochem. Genet. Section Abstract Doc Link 19521764 Disease Relevance 0.19 Pain Relevance 0.16
This gives evidence of a strong relationship between migraine and major vascular diseases and let us hypothesize an important role of ACE and MTHFR system in the pathogenetic model of migraine for its capability to interfere with the endothelial regulation tone.
Regulation (role) of MTHFR associated with migraine and increased venous pressure under development
7) Confidence 0.03 Published 2010 Journal Cent Nerv Syst Agents Med Chem Section Abstract Doc Link 20518725 Disease Relevance 0.92 Pain Relevance 0.47

General Comments

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