INT14205

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.38
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK1) nucleus (KLK1)
Anatomy Link Frequency
plasma 2
uterine 1
KLK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 46 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
anesthesia 3 98.24 Very High Very High Very High
Chronic pancreatitis 2 95.76 Very High Very High Very High
Dismenorea 2 94.60 High High
interstitial cystitis 1 83.60 Quite High
Inflammation 6 81.76 Quite High
cva 14 76.60 Quite High
Pain 11 62.08 Quite High
abdominal pain 1 42.80 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 7 99.32 Very High Very High Very High
Hereditary Angioedema 169 99.00 Very High Very High Very High
Fetal Death 6 98.66 Very High Very High Very High
Pressure And Volume Under Development 73 95.04 Very High Very High Very High
Dysmenorrhea 2 94.60 High High
Myocardial Infarction 13 92.64 High High
Diabetes Mellitus 1 89.68 High High
Disease 14 89.44 High High
Stroke 9 88.88 High High
Hypertension 1 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given its regulatory effects on kallikrein, C1-inhibtor might well have been designated "kallikrein inhibitor."


Regulation (effects) of kallikrein
1) Confidence 0.60 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.47 Pain Relevance 0.17
No effect on routine hematologic and plasma parameters, kallikrein-kinin and factor XII systems was observed.
Neg (No) Regulation (effect) of kallikrein-kinin in plasma
2) Confidence 0.47 Published 1990 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 2361635 Disease Relevance 0.26 Pain Relevance 0.09
Immunoblot assays for detection of changes in the structure of HMWK and prekallikrein may be objective laboratory studies for documenting clinical attacks of hereditary angioedema, their onset, and their resolution.
Regulation (changes) of kallikrein associated with hereditary angioedema
3) Confidence 0.44 Published 1990 Journal J. Lab. Clin. Med. Section Abstract Doc Link 1688910 Disease Relevance 0.24 Pain Relevance 0
Moreover, the separate measurement of bradykinin and kallidin peptides in man demonstrated the differential regulation of the plasma and tissue kallikrein-kinin systems, respectively.
Regulation (regulation) of tissue kallikrein in plasma associated with bradykinin
4) Confidence 0.44 Published 2000 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 10829095 Disease Relevance 0.58 Pain Relevance 0.21
More recently, icatibant, a bradykinin receptor inhibitor, and ecallantide, a kallikrein inhibitor, have been shown to be effective at treating attacks[20,21].
Regulation (effective) of kallikrein associated with bradykinin
5) Confidence 0.44 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2922091 Disease Relevance 0.33 Pain Relevance 0.05
Induction of labor in intrauterine fetal death with 16-phenoxy-prostaglandin-E2-methylsulfonylamide (sulprostone)--effects on uterine contractility, coagulation and kallikrein-kinin systems.
Regulation (--effects) of kallikrein-kinin in uterine associated with fetal death
6) Confidence 0.34 Published 1990 Journal Gynecol. Obstet. Invest. Section Title Doc Link 2361635 Disease Relevance 0.29 Pain Relevance 0.09
[Changes in the kallikrein-kinin system as a result of electrical-medicinal anesthesia].
Regulation ([Changes) of kallikrein-kinin associated with anesthesia
7) Confidence 0.32 Published 1989 Journal Anesteziol Reanimatol Section Title Doc Link 2712382 Disease Relevance 0 Pain Relevance 0.27
The kallikrein inhibitor and the bradykinin receptor-2 antagonist target biologically active products of contact pathway dysregulation caused by C1-inhibitor deficiency.
Regulation (dysregulation) of kallikrein associated with antagonist and bradykinin
8) Confidence 0.26 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.87 Pain Relevance 0.15
Argatroban is highly selective for thrombin and has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein).
Neg (little) Regulation (effect) of kallikrein
9) Confidence 0.26 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721302 Disease Relevance 0.73 Pain Relevance 0.07
Role of the kallikrein-kinin system in human pancreatitis.
Regulation (Role) of kallikrein-kinin associated with pancreatitis
10) Confidence 0.15 Published 1989 Journal Adv. Exp. Med. Biol. Section Title Doc Link 2481954 Disease Relevance 0.61 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox