INT142052

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.02
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) oxidoreductase activity (Snca)
histone binding (Snca) plasma membrane (Snca) cytoskeleton (Snca)
Anatomy Link Frequency
spinal cord 1
astrocytes 1
microglia 1
Snca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.92 Very High Very High Very High
Neuritis 1 97.12 Very High Very High Very High
Inflammation 4 50.00 Quite Low
Neuropeptide 1 42.64 Quite Low
Pain 1 25.00 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 99.86 Very High Very High Very High
Neurodegenerative Disease 5 99.04 Very High Very High Very High
Parkinson's Disease 1 97.96 Very High Very High Very High
Neuritis 1 97.12 Very High Very High Very High
Arrhythmias 2 Under Development 3 88.64 High High
INFLAMMATION 6 80.60 Quite High
Pain 1 25.00 Low Low
Disease Progression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include inflammatory stimulation by interaction of alpha-synuclein with microglia and astrocytes and a suppressive action by nonsteroidal anti-inflammatory drugs on dopamine quinone formation.
alpha-synuclein Binding (interaction) of in astrocytes
1) Confidence 0.47 Published 2007 Journal Curr. Opin. Neurol. Section Body Doc Link 17495632 Disease Relevance 0.08 Pain Relevance 0
One of the most well known characteristics for Parkinson's disease (PD) is a polymerization of wild-type or mutant alpha-synuclein into aggregates and fibrils, commonly observed as Lewy bodies and Lewy neuritis in PD patients.
alpha-synuclein Binding (polymerization) of associated with parkinson's disease, disease and neuritis
2) Confidence 0.31 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17300751 Disease Relevance 0.66 Pain Relevance 0.10
This study provides the first immunohistochemical evidence of the presence and distribution patterns in the rat spinal cord of alpha-synuclein (alpha-Syn), a soluble acidic protein, widely expressed in the CNS and closely associated to the pathogenesis of neurodegenerative conditions such as Parkinson's and Alzheimer's diseases.
alpha-synuclein Binding (associated) of in spinal cord associated with disease, neurodegenerative disease and spinal cord
3) Confidence 0.25 Published 2009 Journal Neuroscience Section Abstract Doc Link 19118601 Disease Relevance 0.20 Pain Relevance 0.12
These include inflammatory stimulation by interaction of alpha-synuclein with microglia and astrocytes and a suppressive action by nonsteroidal anti-inflammatory drugs on dopamine quinone formation.
alpha-synuclein Binding (interaction) of in microglia
4) Confidence 0.16 Published 2007 Journal Curr. Opin. Neurol. Section Body Doc Link 17495632 Disease Relevance 0.08 Pain Relevance 0

General Comments

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