INT142059

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 3.25
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
neurons 11
pituitary gland 3
arcuate nucleus 1
Ghrh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 108 99.76 Very High Very High Very High
amygdala 46 99.48 Very High Very High Very High
antagonist 112 98.32 Very High Very High Very High
depression 46 98.08 Very High Very High Very High
Action potential 142 96.60 Very High Very High Very High
tetrodotoxin 14 95.52 Very High Very High Very High
agonist 59 94.80 High High
Hippocampus 17 93.00 High High
GABAergic 58 90.40 High High
Opioid 9 89.52 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 168 98.24 Very High Very High Very High
Depression 75 98.08 Very High Very High Very High
Diabetes Mellitus 60 95.12 Very High Very High Very High
Post-traumatic Stress Disorder 55 94.56 High High
Stress 43 93.28 High High
Disease 26 93.24 High High
Anxiety Disorder 50 90.40 High High
Aging 30 83.32 Quite High
Sleep Disorders 4 77.52 Quite High
Cushing's Syndrome /

Hypercortisolism

1 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the involvement of glutamatergic neurotransmission in the effect of ghrelin was investigated, since this excitatory transmitter was strongly involved in the muscarinic modulation of GHRH neurons [27].
Regulation (modulation) of GHRH in neurons
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.27
Dual-level afferent control of growth hormone-releasing hormone (GHRH) neurons in GHRH-green fluorescent protein transgenic mice.
Regulation (control) of growth hormone-releasing hormone in neurons associated with targeted disruption
2) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Title Doc Link 17301171 Disease Relevance 0.18 Pain Relevance 0.16
Dual-level afferent control of growth hormone-releasing hormone (GHRH) neurons in GHRH-green fluorescent protein transgenic mice.
Regulation (control) of GHRH in neurons associated with targeted disruption
3) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Title Doc Link 17301171 Disease Relevance 0.18 Pain Relevance 0.16
In both genders, CCh did not change the intrinsic properties of GHRH neurons, although it strongly increased the frequency of glutamatergic currents, in the presence or absence of tetrodotoxin.
Neg (not) Regulation (change) of GHRH in neurons associated with tetrodotoxin
4) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17301171 Disease Relevance 0.14 Pain Relevance 0.45
Ghrelin increased the spontaneous firing rate, but did not modify either the firing pattern or the synchronisation amongst GHRH neurons.
Regulation (synchronisation) of GHRH in neurons
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.13
A modulation of GHRH neuron synaptic currents might play a subtle role in the effect of ghrelin.
Regulation (modulation) of GHRH in neuron
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.22
Perforated patch clamp results showed that ghrelin depolarized GHRH neurons in a tonic manner, and did not significantly modify the kinetics of the spontaneous action potentials.
Regulation (neurons) of GHRH in neurons associated with action potential
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.31
The modulation of GHRH neurons essentially shifted the position of the cumulated distributions in either direction, and did not modify the mean slope of the distributions.
Regulation (modulation) of GHRH in neurons
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.07
On average, 1 µM BIIE 0246 did not change the activity of GHRH neurons in adult male mice (Fig. 6C), although it significantly blunted the stimulatory effect of 100 nM NPY [13]–[36] (n?
Neg (not) Regulation (change) of GHRH in neurons
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.28
There is, however, little evidence for a specific developmental role for IGF-I in the regulation of GHRH neurons, and we cannot exclude the possibility that IGF-1R deletion from other brain areas affected GHRH neurons at a distance.
Regulation (affected) of GHRH in neurons
10) Confidence 0.29 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.19 Pain Relevance 0
The dual-level control could be a mechanism whereby the selective modulation of the GHRH system (short-distance control) is adjusted to the integrated regulation of arcuate nucleus activity (long-distance control).
Regulation (modulation) of GHRH in arcuate nucleus
11) Confidence 0.27 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17301171 Disease Relevance 0.07 Pain Relevance 0.40
There is, however, little evidence for a specific developmental role for IGF-I in the regulation of GHRH neurons, and we cannot exclude the possibility that IGF-1R deletion from other brain areas affected GHRH neurons at a distance.
Regulation (regulation) of GHRH in neurons
12) Confidence 0.17 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.20 Pain Relevance 0
GH is released from the pituitary gland in a pulsatile manner and it is mainly regulated by episodic changes in two hypothalamic hormones, growth hormone-releasing hormone (GHRH) and somatostatin.
Regulation (changes) of GHRH in pituitary gland associated with somatostatin
13) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.19 Pain Relevance 0.19
GH is released from the pituitary gland in a pulsatile manner and it is mainly regulated by episodic changes in two hypothalamic hormones, growth hormone-releasing hormone (GHRH) and somatostatin.
Regulation (changes) of hormone-releasing hormone in pituitary gland associated with somatostatin
14) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.19 Pain Relevance 0.19
Additionally, an adrenal gland lesion evidence have been manifested to not only decrease corticotrophin-releasing hormone-like immunoreactivity in BNST and CeA but also reduce corticotrophin-releasing hormone mRNA in the dorsal part of BNST, and thus the BNST and CeA are the part of extra-hypothalamus-pituitary gland-adrenal gland stress system that probably governs the PTSD-like fear and anxiety responses [43].
Regulation (immunoreactivity) of corticotrophin-releasing hormone in pituitary gland associated with stress, post-traumatic stress disorder, anxiety disorder and amygdala
15) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2867948 Disease Relevance 1.10 Pain Relevance 0.78
Another biological hallmark of MD is the dysregulation of the HPA axis (hyper- or hypo-activity), largely involving pathological alterations in the corticotrophin-releasing hormone (CRH) system (for reviews see [6], [9], [10], [13]–[20]).
Regulation (alterations) of corticotrophin-releasing hormone associated with depression
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.73 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox