INT142064

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 18
Disease Relevance 0.42
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CFL1) cytoskeleton (CFL1) nucleus (CFL1)
intracellular (CFL1) cytoskeleton organization (CFL1) cytoplasm (CFL1)
Anatomy Link Frequency
band 2
CFL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 208 100.00 Very High Very High Very High
qutenza 20 99.32 Very High Very High Very High
imagery 32 19.60 Low Low
Angina 16 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 77.04 Quite High
Targeted Disruption 64 59.80 Quite High
Leukemia 16 50.56 Quite High
Thrombosis 48 24.48 Low Low
Hypertension 64 5.00 Very Low Very Low Very Low
Atherosclerosis 48 5.00 Very Low Very Low Very Low
Disease 32 5.00 Very Low Very Low Very Low
Coronary Artery Disease 16 5.00 Very Low Very Low Very Low
Muscular Spasm 16 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated cofilin was decreased significantly by capsaicin treatment.
Negative_regulation (decreased) of Phosphorylation (Phosphorylated) of cofilin associated with qutenza
1) Confidence 0.56 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.69
The Ca2+-chelating reagent EGTA blocked the cofilin dephosphorylation induced by both capsaicin and ionomycin, suggesting that the dephosphorylation was mediated by Ca2+ influx.
Negative_regulation (blocked) of Phosphorylation (dephosphorylation) of cofilin associated with qutenza
2) Confidence 0.41 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.76
Consistent with this, the specific PGD2 receptor (DP) agonist BW245C also significantly impaired RhoA activation (Fig. 7C) and cofilin phosphorylation in 1° h.AoSMCs.
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin associated with agonist
3) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
led to a further significant reduction in U46619-induced Rho activation and cofilin phosphorylation.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of cofilin
4) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Moreover, the prostacyclin analogue Cicaprost significantly impaired Rho activation (Fig. 9C) and cofilin phosphorylation (Fig. 9D) in 1° h.AoSMCs pre-treated with siRNATP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
5) Confidence 0.19 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Furthermore, this U46619-mediated phosphorylation of cofilin was inhibited by over-expression of the dominant negative form of G?
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of cofilin
6) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.14 Pain Relevance 0
Similarly, while the NO donors SIN-1 and FK409 alone did not induce substantial RhoA signaling relative to the drug vehicle per se, they each significantly impaired U46619-induced RhoA activation and cofilin phosphorylation following their pre-incubation in 1° h.AoSMCs (Fig. 7B and D).
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
7) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
also impaired U46619-mediated F-actin polymerization and cofilin phosphorylation in HEK.TP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
8) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.11 Pain Relevance 0
Moreover, Cicaprost (IP agonist) and BW245C (DP agonist) and the NO donors SIN-1 and FK409 each significantly impaired such U46619-induced RhoA activation, F-actin polymerization and cofilin phosphorylation in 1° h.AoSMCs.
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin associated with agonist
9) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
While SIN-1 and Cicaprost significantly impaired U46619-mediated RhoA activation in the presence of the siRNA directed to Lamin A/C to levels similar to that in vehicle-treated cells, the inhibitory action of both agents on RhoA activation and cofilin phosphorylation in 1° h.AoSMCs exposed to the siRNATP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
10) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0
Additionally, SIN-1 and FK409 also impaired U46619-induced F-actin polymerization, at low agonist concentration, and cofilin phosphorylation by TP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin associated with agonist
11) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
Stimulation of 1° h.AoSMCs also led to rapid F-actin polymerization (Fig. 6B) and cofilin phosphorylation with optimal responses generated using 1 ?
Negative_regulation (polymerization) of Phosphorylation (phosphorylation) of cofilin
12) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.11
All images of RhoA expression/pulldown or cofilin phosphorylation and/or expression were captured using Adobe Photoshop (V6), where band width and intensity was quantified and represented as fold increases relative to basal levels.
Negative_regulation (pulldown) of Phosphorylation (phosphorylation) of cofilin in band
13) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
M) effectively abolished U46619-induced cofilin phosphorylation by both TP?
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of cofilin
14) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.07 Pain Relevance 0
Similarly, SIN-1 impaired U46619-mediated cofilin phosphorylation in the presence of siRNATP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
15) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
-mediated RhoA activation, F-actin polymerization and cofilin phosphorylation was also specifically impaired by Cicaprost and SIN-1 while neither agent affected Rho-mediated signaling by TP?.
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
16) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0
Additionally, Cicaprost specifically impaired U46619-induced F-actin polymerization and cofilin phosphorylation by TP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of cofilin
17) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.12
following incubation of the 1° h.AoSMCs with the isoform-specific siRNAs, there were reductions in U46619-induced Rho activation and cofilin phosphorylation in the presence of RNAi directed to either TP but not directed to Lamin A/C (Fig. 9B).
Negative_regulation (reductions) of Phosphorylation (phosphorylation) of cofilin
18) Confidence 0.14 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox