INT142065

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 41
Disease Relevance 0.87
Pain Relevance 6.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CFL1) cytoskeleton (CFL1) nucleus (CFL1)
intracellular (CFL1) cytoskeleton organization (CFL1) cytoplasm (CFL1)
Anatomy Link Frequency
intestinal cells 2
Caco-2 1
band 1
CFL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 70 99.82 Very High Very High Very High
agonist 442 99.60 Very High Very High Very High
imagery 68 85.40 High High
Angina 34 24.40 Low Low
antagonist 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 102 95.96 Very High Very High Very High
Leukemia 34 84.88 Quite High
Thrombosis 102 63.04 Quite High
Targeted Disruption 136 60.24 Quite High
Disease 68 47.84 Quite Low
Coronary Artery Disease 34 28.00 Quite Low
Hypertension 136 26.92 Quite Low
Atherosclerosis 102 25.08 Quite Low
Cv General 3 Under Development 34 24.40 Low Low
Myocardial Infarction 34 23.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated cofilin was decreased significantly by capsaicin treatment.
Phosphorylation (Phosphorylated) of cofilin associated with qutenza
1) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.68
Capsaicin induces cofilin dephosphorylation in human intestinal cells: the triggering role of cofilin in tight-junction signaling.
Phosphorylation (dephosphorylation) of cofilin in intestinal cells associated with qutenza
2) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.83
This is the first report of capsaicin action via the dephosphorylation of cofilin in human intestinal cells.
Phosphorylation (dephosphorylation) of cofilin in intestinal cells associated with qutenza
3) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.71
Our data suggest that TJ opening is mediated by cofilin dephosphorylation, which is caused by capsaicin stimuli, including Ca2+ influx.
Phosphorylation (dephosphorylation) of cofilin associated with qutenza
4) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.73
The Ca2+-chelating reagent EGTA blocked the cofilin dephosphorylation induced by both capsaicin and ionomycin, suggesting that the dephosphorylation was mediated by Ca2+ influx.
Phosphorylation (dephosphorylation) of cofilin associated with qutenza
5) Confidence 0.78 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.76
Finally, transepithelial electrical resistance measurements showed that TJ opening accompanied cofilin dephosphorylation.
Phosphorylation (dephosphorylation) of cofilin
6) Confidence 0.68 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.74
In addition, capsaicin induced Ca2+ influx in Caco-2 cells and there was a clear correlation between Ca2+) influx and cofilin dephosphorylation (activation).
Phosphorylation (dephosphorylation) of cofilin in Caco-2 associated with qutenza
7) Confidence 0.52 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17303079 Disease Relevance 0 Pain Relevance 0.75
Similarly, while the NO donors SIN-1 and FK409 alone did not induce substantial RhoA signaling relative to the drug vehicle per se, they each significantly impaired U46619-induced RhoA activation and cofilin phosphorylation following their pre-incubation in 1° h.AoSMCs (Fig. 7B and D).
Phosphorylation (phosphorylation) of cofilin
8) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
expressed in HEK 293 cells readily induced RhoA activation, F-actin polymerization and cofilin phosphorylation in response to U46619.
Phosphorylation (phosphorylation) of cofilin
9) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.04
Stimulation of 1° h.AoSMCs also led to rapid F-actin polymerization (Fig. 6B) and cofilin phosphorylation with optimal responses generated using 1 ?
Phosphorylation (phosphorylation) of cofilin
10) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.11
Consistent with their reduced expression in the 1° h.AoSMCs, there was a significant reduction in U46619-mediated Rho activation and cofilin phosphorylation in the presence of RNAi directed to either TP?
Phosphorylation (phosphorylation) of cofilin
11) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
Moreover, U46619-induced cofilin phosphorylation by TP?
Phosphorylation (phosphorylation) of cofilin
12) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
activation to mobilize Ca2+ from IP3-operated intracellular stores, for example, and to G12-dependent RhoA activation and effector coupling leading to cofilin phosphorylation and inactivation and to F-actin polymerization.


Phosphorylation (phosphorylation) of cofilin
13) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0
Moreover, the prostacyclin analogue Cicaprost significantly impaired Rho activation (Fig. 9C) and cofilin phosphorylation (Fig. 9D) in 1° h.AoSMCs pre-treated with siRNATP?
Phosphorylation (phosphorylation) of cofilin
14) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
activation, both the NO and prostacyclin analogues SIN-1 and Cicaprost impair TP-mediated cytoskeletal changes involving RhoA activation and cofilin phosphorylation in 1° h.AoSMCs and that they do so, at least in part, by specifically and directly targeting TP?
Phosphorylation (phosphorylation) of cofilin
15) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
both SIN-1 and Cicaprost reduced U46619-mediated RhoA, F-actin polymerization (data not shown) and cofilin phosphorylation to levels not significantly different to those observed in vehicle-treated cells.
Phosphorylation (phosphorylation) of cofilin
16) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
following incubation of the 1° h.AoSMCs with the isoform-specific siRNAs, there were reductions in U46619-induced Rho activation and cofilin phosphorylation in the presence of RNAi directed to either TP but not directed to Lamin A/C (Fig. 9B).
Phosphorylation (phosphorylation) of cofilin
17) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Hence, both the NO and prostacyclin impair TP-mediated cytoskeletal changes involving RhoA activation, F-actin polymerization and cofilin phosphorylation in 1° h.AoSMCs and they do so, at least in part, by specifically and directly targeting TP?
Phosphorylation (phosphorylation) of cofilin
18) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with the latter data, the PGD2 analogue BW245C and the alternative NO donor FK409 also significantly impaired U46619-mediated RhoA activation (Fig. 3C) and cofilin phosphorylation (data not shown) by TP?
Phosphorylation (phosphorylation) of cofilin
19) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Similarly, SIN-1 impaired U46619-mediated cofilin phosphorylation in the presence of siRNATP?
Phosphorylation (phosphorylation) of cofilin
20) Confidence 0.26 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox