INT142076

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.58
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4, IFNG) extracellular region (IL4, IFNG)
Anatomy Link Frequency
monocytes 2
IL4 (Homo sapiens)
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 98.36 Very High Very High Very High
headache 9 75.00 Quite High
Inflammation 6 75.00 Quite High
Central nervous system 6 74.72 Quite High
Migraine 1 54.72 Quite High
cva 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cerebral Toxoplasmosis 2 99.64 Very High Very High Very High
Cyst 1 95.76 Very High Very High Very High
Rupture 1 95.52 Very High Very High Very High
Infection 5 92.28 High High
Eczema 1 91.04 High High
Toxoplasmosis 2 78.56 Quite High
Headache 10 75.00 Quite High
Immunodeficiency 2 75.00 Quite High
Neurogenic Inflammation 1 75.00 Quite High
Lymphadenopathy 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cytokine irregularities caused limited control of cerebral toxoplasmosis probably because IL-4 down-regulated both the production of IFN-gamma and its activity, and stimulated production of a low NO-producing population of monocytes, which allowed cysts rupture, increased parasite multiplication and finally reactivation of T. gondii infection.
IL-4 Negative_regulation (down-regulated) of Gene_expression (production) of IFN-gamma in monocytes associated with cerebral toxoplasmosis, rupture, cyst, infection and cytokine
1) Confidence 0.01 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.58 Pain Relevance 0.64

General Comments

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