INT142077

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.07
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (IDO1) aging (TGFB1) enzyme binding (TGFB1)
embryo development (TGFB1) cytoplasm (TGFB1) cytosol (IDO1)
Anatomy Link Frequency
fibroblasts 3
monocytes 1
TGFB1 (Homo sapiens)
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 93.40 High High
Inflammation 12 91.36 High High
cva 4 82.64 Quite High
headache 18 75.00 Quite High
Central nervous system 12 54.40 Quite High
Migraine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 91.36 High High
Pseudotumor Cerebri 4 83.52 Quite High
Viral Meningitis 2 78.48 Quite High
Headache 20 75.00 Quite High
Cerebral Toxoplasmosis 4 75.00 Quite High
Immunodeficiency 4 75.00 Quite High
Neurogenic Inflammation 2 75.00 Quite High
Lymphadenopathy 2 75.00 Quite High
Infection 10 53.28 Quite High
Neurologic Manifestations 2 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, IL-4 and TGF-beta can suppress IDO activity in some cells, for example human monocytes and fibroblasts, which is consistent with metabolic pathways controlled by IDO being a significant contributor to the proinflammatory system.
TGF-beta Negative_regulation (suppress) of IDO Binding (activity) of in fibroblasts
1) Confidence 0.15 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.03 Pain Relevance 0.59
On the other hand, IL-4 and TGF-beta can suppress IDO activity in some cells, for example human monocytes and fibroblasts, which is consistent with metabolic pathways controlled by IDO being a significant contributor to the proinflammatory system.
TGF-beta Negative_regulation (suppress) of IDO in monocytes Binding (activity) of in fibroblasts
2) Confidence 0.05 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.03 Pain Relevance 0.59

General Comments

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