INT142078

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 92.08 High High
headache 18 78.52 Quite High
cytokine 10 77.04 Quite High
Pain 29 60.80 Quite High
visual analogue scale 10 59.84 Quite High
Pain score 7 53.92 Quite High
Central nervous system 12 51.12 Quite High
c fibre 11 48.56 Quite Low
unmyelinated 6 48.20 Quite Low
cva 4 39.76 Quite Low
Disease Link Frequency Relevance Heat
Bladder Disease 34 99.80 Very High Very High Very High
INFLAMMATION 15 92.08 High High
Headache 20 78.52 Quite High
Immunodeficiency 4 75.00 Quite High
Cerebral Toxoplasmosis 4 75.00 Quite High
Lymphadenopathy 2 75.00 Quite High
Neurogenic Inflammation 2 75.00 Quite High
Infection 10 63.24 Quite High
Pain 23 60.80 Quite High
Urinary Tract Disease 2 41.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, NO inhibits IDO activity, thereby suppressing kynurenine formation, and at least one member of the kynurenine pathway, 3-hydroxyanthranilic acid, has been shown to inhibit NOS enzyme activity, the expression of NOS mRNA, and activation of the inflammatory transcription factor, nuclear factor-kB.
Negative_regulation (suppressing) of IDO associated with inflammation
1) Confidence 0.14 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 0.93 Pain Relevance 0.54
Moreover, NO inhibits IDO activity, thereby suppressing kynurenine formation, and at least one member of the kynurenine pathway, 3-hydroxyanthranilic acid, has been shown to inhibit NOS enzyme activity, the expression of NOS mRNA, and activation of the inflammatory transcription factor, nuclear factor-kB.
Negative_regulation (inhibits) of IDO associated with inflammation
2) Confidence 0.14 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 0.93 Pain Relevance 0.54
Compared to controls, a three- and five-fold increase of TRPM8-immunoreactive axons was seen in IDO and PBS groups respectively.
Negative_regulation (seen) of IDO associated with bladder disease
3) Confidence 0.11 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.73 Pain Relevance 0.14

General Comments

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